TOXICITY OF ZINC OXIDE NANOPARTICLES ON HUMAN SKIN DERMAL CELLS

Harshyini  Maheswaran; Ling Shing  Wong; Anto Cordelia Tanislaus Antony  Dhanapal; Ramasamy Thangavelu  Narendhirakannan; Ashok Kumar  Janakiraman; Sinouvassane  Djearamane

doi:10.18006/2021.9(Spl-1-GCSGD_2020).S95.S100

Authors

Harshyini Maheswaran Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, 31900 Malaysia
Ling Shing Wong Life Science Division, Faculty of Health and Life Sciences, INTI International University, Nilai, 71800 Malaysia
Anto Cordelia Tanislaus Antony Dhanapal Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, 31900 Malaysia
Ramasamy Thangavelu Narendhirakannan Department of Biochemistry, Kongunadu Arts and Science College, Affiliated to Bharathiar University, Coimbatore, Tamil Nadu, India
Ashok Kumar Janakiraman Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia
Sinouvassane Djearamane Department of Biomedical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Kampar, 31900 Malaysia

DOI:

https://doi.org/10.18006/2021.9(Spl-1-GCSGD_2020).S95.S100

Keywords:

Zinc oxide nanoparticles, Zinc, Skin dermal cells, Toxicity

Abstract

Zinc oxide (ZnO) has special physical and chemical characteristics which enable it to be utilized in numerous applications including electronics, sunscreens, pigments, and most notably in biomedical applications. Nanoemulsions containing zinc oxide nanoparticles (ZnO NPs) are progressively sought-after as an active component in cosmetic formulations and are used in sunscreens, moisturizers, and antiaging products. Zinc paste bandages including Unna boot consist of open wove cotton gauze treated with ZnO paste are now common medicaments for leg ulcers. The damaged and broken skins are vulnerable to ZnO NPs uptake. This being the case, ZnO NPs on the skin surface can affect the functions of surrounding cells in numerous ways by penetrating into the skin cells. This could exert toxicity effects on the skin cells over time depending on the concentration and site of ZnO NPs exposure. This review brings together some findings regarding the toxicity of ZnO NPs on human skin dermal cells and thus in turn enlightens the safer usage of ZnO NPs in skin care applications.

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