ROLE OF INTERLEUKIN-2, INTERLEUKIN-4 AND CLUSTER OF DIFFERENTIATION-22 AS AN IMMUNE MARKERS IN INDIVIDUALS INFECTED WITH Helicobacter pylori

Jaffar Muhammad Baqir Muhammad  Rashad; Ahmed Abdul jabbar Jaloob  Aljanaby

doi:10.18006/2021.9(3).388.393

Authors

Jaffar Muhammad Baqir Muhammad Rashad Department of biology, Faculty of Science, University of Kufa, Iraq
Ahmed Abdul jabbar Jaloob Aljanaby Department of biology, Faculty of Science, University of Kufa, Iraq https://orcid.org/0000-0002-9817-3318

DOI:

https://doi.org/10.18006/2021.9(3).388.393

Keywords:

Helicobacter pylori, Immune response, IL-2, IL-4, CD22, Iraq

Abstract

Helicobacter pylori is a gram-negative, intracellular, microaerophilic bacteria which causing Peptic ulcer. This bacterium can change its shape which helps the bacteria to survive in the host gastric microenvironment. The Peptic ulcer caused by this bacterium stimulates the humoral and cellular immune response in individuals. The current study was carried out to access the role of interleukin-2, interleukin-4, and cluster differentiation-22 as immune markers in the identification of H. pylori infection. The presence of H. pylori has been diagnosed by feces test (antigen rapid test). In this study, the presence of three immunological markers viz., IL-2, IL-4, and CD22 were measured in the serum of 60 individuals infected with H. pylori and 30 healthy individuals by the Enzyme-Linked Immune-sorbent Assay method. Results of this study indicated a significant increase (P-value=0.0307^*) in the concentration of IL-2 (294.27ng/ml), IL-4(151.28ng/ml), and CD22 (492.73ng/ml) in the serum of individuals infected with H. pylori while these concentrations were reported 235.98ng/ml, 116.14ng/ml and 369.33ng/ml respectively in the healthy individuals. Results of the study can be concluded that H.pylori infection stimulates the Cellular and humoral immune response which resulted in the increased production of IL-2, IL-4, and CD22.

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