Ovarian Gene Transcriptional Responses To Antidepressant Drugs (Imipramine And Fluoxetine) In Female Wistar Rats

Oyedeji K.O.; Uwadiale D.

doi:10.18006/2023.11(3).593.597

Authors

Oyedeji K.O. Physiology Department, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria
Uwadiale D. Physiology Department, College of Medicine and Health Sciences, Afe Babalola University, Ado-Ekiti, Nigeria

DOI:

https://doi.org/10.18006/2023.11(3).593.597

Keywords:

Imipramine, Fluoxetine, Gene, RT-PCR, Bcl-2, Rats

Abstract

This study was designed to investigate ovarian gene transcriptional responses to selected antidepressant drugs (imipramine and fluoxetine) in female rats. Fifteen female rats (120 – 140 g) were used for this study. Imipramine (0.71 mg/kg) and fluoxetine (0.57 mg/kg) were given orally for 50 days. The method of RT-PCR was employed to investigate the expressions of FSH-R, p53 and Bcl-2 genes. Graphics were generated as mean +/- SEM using GraphPad Prism version 8.0. Results of the study revealed that the FSH-R, p53 and Bcl-2 expressions were significantly (p<0.05) up-regulated in the imipramine-treated rats relative to their controls. Conclusively, it can be suggested that imipramine induced follicular growth and apoptosis in female Wistar rats.

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