Colistin the last resort drug in 21st century antibiotics to combat Multidrug resistance superbugs

Swayamprabha Sahoo; Jatindra Nath Mohanty; Sweta Padma  Routray; Rekha Khandia; Jayashankar Das; Sejal Shah; Tripti Swarnkar

doi:10.18006/2023.11(6).919.929

Authors

Swayamprabha Sahoo Centre for Biotechnology, Siksha "O" Anusandhan (Deemed to be) University, Bhubaneswar-751003, India https://orcid.org/0000-0002-8204-8790
Jatindra Nath Mohanty School of Applied Sciences, Centurion University of Technology and Management, Ramachandrapur, Jatni-752050, Bhubaneswar, Odisha, India https://orcid.org/0000-0001-9228-8395
Sweta Padma Routray Centre for Biotechnology, Siksha "O" Anusandhan (Deemed to be) University, Bhubaneswar-751003, India https://orcid.org/0000-0002-1402-5909
Rekha Khandia Department of Genetics, Barkatullah University, Bhopal 462026, M.P., India https://orcid.org/0000-0002-9961-3127
Jayashankar Das Director, Valnizenhealthcare, VileParle, Mumbai, India https://orcid.org/0000-0002-7131-757X
Sejal Shah Department of Microbiology, Faculty of Science, Marwadi University, Rajkot, India-360003 https://orcid.org/0000-0002-7664-4086
Tripti Swarnkar Department of Computer Application, Siksha' O' Anusandhan Deemed to be University, Bhubaneswar, India https://orcid.org/0000-0002-1853-4874

DOI:

https://doi.org/10.18006/2023.11(6).919.929

Keywords:

Polymyxin E, MDR, Antimicrobial Resistance, Drug repurposing

Abstract

Polymyxin' E' (Colistin) is considered the last resort therapy against Multidrug resistance (MDR) bacteria, mainly Klebsiella peumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Escherichia coli and play a critical role in causing life-threatening infection, and their prevalence is increasing as a big concern globally. Apart from immunological adaptation, chromosomal mutations and plasmid-mediated genes are mostly associated with this resistance at the molecular level. Therefore, the current review extensively focused on Colistin as a drug in 21st-century antibiotics, the activities spectrum with diverse resistance mechanisms of bacteria against Colistin, and emerging approaches of Colistin from discovery to tackling MDR. In the study, we got to know about the challenges and new developments with old weapons like phage therapy as well as new approaches like Phage display and drug repurposing, in addition to the chromosomal and plasmid-mediated genes that play a role in antimicrobial resistance (AMR). The present study would provide insight into the prognostic aspect of combating MDR.

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