Donkey milk: chemical make-up, biochemical features, nutritional worth, and possible human health benefits - Current state of scientific knowledge

Authors

  • Deepa P R Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, Tamil Nadu– 642109, India
  • Divya Dharshini C S Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, Tamil Nadu– 642109, India
  • Bhadra S Dev Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, Tamil Nadu– 642109, India
  • Jyotika Jayan Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, Tamil Nadu– 642109, India
  • Harisankaran P S Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, Tamil Nadu– 642109, India
  • Nithin S Rajan Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, Tamil Nadu– 642109, India
  • Karthik S Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, Tamil Nadu– 642109, India
  • Nandhana J P Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, Tamil Nadu– 642109, India
  • Athulya K G Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, Tamil Nadu– 642109, India
  • Pran M School of Agricultural Sciences, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu– 641114, India https://orcid.org/0000-0001-8952-7893
  • Sandip Chakraborty Department of Veterinary Microbiology, College of Veterinary Sciences and Animal Husbandry, R.K. Nagar, West Tripura, Tripura, Pin-799008, India https://orcid.org/0000-0002-2792-3281
  • Hitesh Chopra Chitkara College of Pharmacy, Chitkara University, Punjab - 140401, India https://orcid.org/0000-0001-8867-7603
  • Abhijit Dey Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata-700073, West Bengal, India https://orcid.org/0000-0002-5750-0802
  • Anil K Sharma Department of Biotechnology, Maharishi Markandeshwar University (Deemed to be University) Mullana-Ambala-133207, Haryana, India https://orcid.org/0000-0002-9768-1644
  • Kuldeep Dhama Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India - 243122 https://orcid.org/0000-0001-7469-4752
  • Deepak Chandran Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, Tamil Nadu– 642109, India https://orcid.org/0000-0002-9873-6969

DOI:

https://doi.org/10.18006/2023.11(2).251.263

Keywords:

Donkey milk, Nutritional profile, Medicinal value, Functional food

Abstract

Milk and milk derivatives are widely consumed because of their high nutritional density. Donkey milk and milk products have been consumed since ancient times. The use of donkey milk in the human diet is gaining popularity. The abundance of antibacterial components and protective elements in donkey milk sets it apart from the milk of other animals. Like human milk, donkey milk has low fat, high lactose, and low casein/whey protein ratio. Donkey milk whey protein's anti-proliferative properties imply lung cancer treatment. Alpha-lactalbumin, a type of protein, has been found to have antiviral, anticancer, and anti-stress properties. Donkey milk, like human milk, includes a low amount of casein and a smaller quantity of beta-lactoglobulin than cow milk. Donkey milk is an alternative for newborns with cow milk protein allergy and lactose intolerance since it has a higher amount of lactose, improves palatability, and prevents allergies. Osteogenesis, arteriosclerosis therapy, cardiac rehabilitation, accelerated aging, and hypocholesterolemic diets are some areas where donkey milk is beneficial. Since it contains probiotic lactobacilli strains, fermented beverages can be made with donkey milk. Donkey milk moisturizes skin due to its high vitamin, mineral, and polyunsaturated fatty acid content. The chemical makeup and potential therapeutic benefits of donkey milk warrant additional research. This has led to a rise in interest in producing dairy goods derived from donkey milk. Donkey milk has been used to make cheese, ice cream, milk powder, and even some experimental useful fermented drinks. The present article summarises what we know about donkey milk's chemical makeup, biological functions, nutritional worth, and possible human health benefits.

References

Aspri, M., Economou, N., & Papademas, P. (2017). Donkey milk: An overview on functionality, technology, and future prospects. Food Reviews International, 33(3), 316-333. https://doi.org/10.1080/87559129.2016.1175014 DOI: https://doi.org/10.1080/87559129.2016.1175014

Baloš, M.Ž., Pelić, D.L., Jakšić, S., & Lazić, S. (2023). Donkey Milk: An Overview of its chemical composition and main nutritional properties or Human Health Benefit Properties. Journal of Equine Veterinary Science, 121, 104225. https://doi.org/10.1016/j.jevs.2023.104225 DOI: https://doi.org/10.1016/j.jevs.2023.104225

Bertino, E., Agosti, M., Peila, C., Corridori, M., Pintus, R., & Fanos, V. (2022). The donkey milk in infant nutrition. Nutrients, 14(3), 403. https://doi.org/10.3390/nu14030403 DOI: https://doi.org/10.3390/nu14030403

Bhardwaj, A., Pal, Y., Legha, R.A., Sharma, P., Nayan, V., Kumar, S., Tripathi, H., & Tripathi, B.N. (2020). Donkey milk composition and its therapeutic applications. Indian Journal of Animal Sciences, 90(6), 837-841. DOI: https://doi.org/10.56093/ijans.v90i6.104972

Brumini, D., Criscione, A., Bordonaro, S., Vegarud, G.E., & Marletta, D. (2016). Whey proteins and their antimicrobial properties in donkey milk: a brief review. Dairy Science & Technology, 96, 1-14. https://doi.org/10.1007/s13594-015-0246-1 DOI: https://doi.org/10.1007/s13594-015-0246-1

Chandran, D., & Radhakrishnan, U. (2019). Lactoferrin: A General Review. International Journal of Pharmaceutical Sciences Review and Research, 58(2), 65-75. DOI: https://doi.org/10.47583/ijpsrr.2020.v65i02.018

Chandran, D., Radhakrishnan, U., & Eldho, L. (2020). Characterization of Malabari goat lactoferrin and its pepsin hydro-lysate. Journal of Veterinary and Animal Sciences, 51(1), 40-47.

Chandran, D., Lejaniya, A.S., Yatoo, M.I., Mohapatra, R.K., & Dhama, K. (2021). Major health effects of casein and whey proteins present in cow Milk: A narrative review. The Indian Veterinary Journal, 98(11), 9-19.

Cimmino, F., Catapano, A., Villano, I., Di Maio, G., Petrella, L., Traina, G., Pizzella, A., Tudisco, R., & Cavaliere, G. (2023). Invited review: Human, cow, and donkey milk comparison: Focus on metabolic effects. Journal of Dairy Science. https://doi.org/10.3168/jds.2022-22465 DOI: https://doi.org/10.3168/jds.2022-22465

Conte, F., & Panebianco, A. (2019). Potential hazards associated with raw donkey milk consumption: A review. International Journal of Food Science, https://doi.org/10.1155/2019/5782974 DOI: https://doi.org/10.1155/2019/5782974

Cosentino, C., Paolino, R., Valentini, V., Musto, M., Ricciardi, A., Adduci, F., D'adamo, C., Pecora, G., & Freschi, P. (2015). Effect of jenny milk addition on the inhibition of late blowing in semihard cheese. Journal of Dairy Science, 98(8), 5133-5142. https://doi.org/10.3168/jds.2015-9458 DOI: https://doi.org/10.3168/jds.2015-9458

Cosentino, C., Faraone, D., Paolino, R., Freschi, P., & Musto, M. (2016). Sensory profile and acceptability of a cow milk cheese manufactured by adding jenny milk. Journal of Dairy Science, 99(1), 228-233. https://doi.org/10.3168/jds.2015-10107 DOI: https://doi.org/10.3168/jds.2015-10107

Cosentino, C., Paolino, R., Rubino, M., & Freschi, P. (2022). Effect of the addition of donkey milk on the acceptability of caciotta cow cheese. Animals, 12(11), 1444. https://doi.org/ 10.3390/ani12111444 DOI: https://doi.org/10.3390/ani12111444

Derdak, R., Sakoui, S., Pop, O.L., Muresan, C.I., Vodnar, D.C., Addoum, B., Vulturar, R., Chis, A., Suharoschi, R., Soukri, A., & El Khalfi, B. (2020). Insights on health and food applications of Equus asinus (Donkey) milk bioactive proteins and peptides—an Overview. Foods, 9(9), 1302. https://doi.org/10.3390/foods9091302 DOI: https://doi.org/10.3390/foods9091302

Garhwal, R., Sangwan, K., Mehra, R., Kumar, N., Bhardwaj, A., Pal, Y., Buttar, H.S., & Kumar, H. (2022). A systematic review of the bioactive components, nutritional qualities and potential therapeutic applications of donkey milk. Journal of Equine Veterinary Science, 115, 104006. https://doi.org/10.1016/ j.jevs.2022.104006 DOI: https://doi.org/10.1016/j.jevs.2022.104006

Karami, Z., & Akbari-adergani, B. (2019). Bioactive food derived peptides: A review on correlation between structure of bioactive peptides and their functional properties. Journal of Food Science and Technology, 56, 535–547. https://doi.org/10.1007/s13197-018-3549-4 DOI: https://doi.org/10.1007/s13197-018-3549-4

Kumar, K.S., Chandran, D., Yatoo, M.I., Mohapatra, R.K., & Dhama, K. (2021). Major health effects of casein and whey proteins present in cow milk: A narrative review. Indian Veterinary Journal, 98(11), 9-19.

Kumari, A., & Sharma, P. (2021). The nutraceutical characteristics of donkey milk: A new insight for its potential probiotics. Journal of Veterinary Medicine and Animal Sciences, 4(2), 1074.

Lejaniya, A.S., Chandran, D., Venkatachalapathy, T., Bashir, B.P., Kumar, M., Shanavas, A., Sureshkumar, R., Kumar, P.N., Sabareeshwari, V., Kumar, K.K., & Mohankumar, P. (2021a). Analysis of milk production performance of Attappadi Black, Malabari and cross-bred goats under organized farm conditions of Kerala. The Indian Veterinary Journal, 98(05), 13-19.

Lejaniya, A.S., Chandran, D., & Geetha, R. (2021b). Recent trends in application of lactic acid bacteria (LAB) in dairy and biomedical industry: A critical review. World Journal of Pharmaceutical Research, 10(12), 577-591. doi: 10.20959/wjpr202112-21749.

Madhusudan, N.C., Ramachandra, C.D., Udaykumar, N.D., Sharnagouda, H.D., Nagraj, N.D., & Jagjivan, R.D. (2017). Composition, characteristics, nutritional value and health benefits of donkey milk-a review. Dairy Science & Technology, 2017, hal-01538532. Retrieved from http://efaidnbmnnnibpcajpcglclefind mkaj/https://hal.science/hal-01538532v1/document.

Malissiova, E., Arsenos, G., Papademas, P., Fletouris, D., Manouras, A., Aspri, M., Nikolopoulou, A., Giannopoulou, A., & Arvanitoyannis, I.S. (2016). Assessment of donkey milk chemical, microbiological and sensory attributes in Greece and Cyprus. International Journal of Dairy Technology, 69(1), 143-146. https://doi.org/10.1111/1471-0307.12245 DOI: https://doi.org/10.1111/1471-0307.12245

Martini, M., Altomonte, I., Licitra, R., & Salari, F. (2018a); Nutritional and Nutraceutical Quality of Donkey Milk. Journal of Equine Veterinary Science, 65, 33–37. https://doi.org/10.1016/ j.jevs.2017.10.020 DOI: https://doi.org/10.1016/j.jevs.2017.10.020

Martini, M., Altomonte, I., Tricò, D., Lapenta, R., & Salari, F. (2021). Current knowledge on functionality and potential therapeutic uses of donkey milk. Animals, 11(5), 1382. https://doi.org/10.3390/ani11051382 DOI: https://doi.org/10.3390/ani11051382

Martini, M., Salari, F., Altomonte, I., Ragona, G., Piazza, A., Gori, R., Casati, D., & Brajon, G. (2018b). Effects of pasteurization and storage conditions on donkey milk nutritional and hygienic characteristics. Journal of Dairy Research, 85(4), 445-448. https://doi.org/10.1017/S0022029918000687 DOI: https://doi.org/10.1017/S0022029918000687

Massouras, T., Bitsi, N., Paramithiotis, S., Manolopoulou, E., Drosinos, E.H., & Triantaphyllopoulos, K.A. (2020). Microbial profile antibacterial properties and chemical composition of raw donkey milk. Animals, 10(11), 2001. https://doi.org/10.3390/ ani10112001 DOI: https://doi.org/10.3390/ani10112001

Mottola, A., Alberghini, L., Giaccone, V., Marchetti, P., Tantillo, G., & Di Pinto, A. (2018). Microbiological safety and quality of Italian donkey milk. Journal of Food Safety, 38(3), 12444. https://doi.org/10.1111/jfs.12444 DOI: https://doi.org/10.1111/jfs.12444

Murua, A., Todorov, S.D., Vieira, A.D.S., Martinez, R.C.R., Cencič, A., & Franco, B.D.G.D.M. (2013). Isolation and identification of bacteriocinogenic strain of Lactobacillus plantarum with potential beneficial properties from donkey milk. Journal of Applied microbiology, 114(6), 1793-1809. https://doi.org/10.1111/jam.12190 DOI: https://doi.org/10.1111/jam.12190

Nazzaro, F., Fratianni, F., Orlando, P., & Coppola, R. (2010). The use of probiotic strains in the production of a donkey milk-based functional beverage. International Journal of Probiotics & Prebiotics, 5(2), 91.

Papademas, P., Mousikos, P., & Aspri, M. (2022). Valorization of donkey milk: Technology, functionality, and future prospects. JDS communications, 3(3), 228-233. https://doi.org/10.3168/jdsc.2021-0175 DOI: https://doi.org/10.3168/jdsc.2021-0175

Patange, D.D.D., Virshasen Vinayak, D., Chandran, D., Kumar, M., & Lorenzo, J.M. (2022a). Comparative effect of cooling on the physico-chemical-sensory properties of ghee from cow and buffalo milk, and evaluation of the low-fat spread prepared from cow and buffalo milk ghee. Food Analytical Methods, 1-11. doi:10.1007/s12161-022-02312-4. DOI: https://doi.org/10.1007/s12161-022-02312-4

Patange, D.D., Pansare, K.S., Kumar, M., Kumari, A., Kamble, D.K., Chandran, D., Gaikwad, N.B., Waghmare, R., & Lorenzo, J.M. (2022b). Studies on utilization and shelf life of Piper betel leaves added ghee-based low-fat spread. Food Analytical Methods, 1-12. doi: 10.1007/s12161-022-02400-5. DOI: https://doi.org/10.1007/s12161-022-02400-5

Peng, S., Yang, Y., Li, S., Wu, Q., Shah, N.P., Wei, H., & Xu, F. (2014). Immunomodulatory activities of Lactobacillus rhamnosus ZDY114 and donkey milk in BALB/c mice. International Dairy Journal, 34(2), 263-266. https://doi.org/10.1016/j.idairyj.2013.07.018 DOI: https://doi.org/10.1016/j.idairyj.2013.07.018

Perna, A., Intaglietta, I., Simonetti, A., & Gambacorta, E. (2015). Donkey milk for manufacture of novel functional fermented beverages. Journal of Food Science, 80(6), 1352-1359. https://doi.org/10.1111/1750-3841.12862 DOI: https://doi.org/10.1111/1750-3841.12862

Pilla, R., Dapra, V., Zecconi, A., & Piccinini, R. (2010). Hygienic and health characteristics of donkey milk during a follow-up study. Journal of Dairy Research, 77(4), 392-397. DOI: https://doi.org/10.1017/S0022029910000221

Prasad, B. (2020). Nutritional and health benefits of donkey milk. Journal of Food Science and Nutrition Therapy, 6(1), 22-25.

Ragona, G., Corrias, F., Benedetti, M., Paladini, M., Salari, F., & Martini, M. (2016). Amiata donkey milk chain: animal health evaluation and milk quality. Italian Journal of Food Safety, 5(3). https://doi.org/10.4081%2Fijfs.2016.5951 DOI: https://doi.org/10.4081/ijfs.2016.5951

Saleena, L.A.K., Chandran, D., Geetha, R., Radha, R., & Sathian, C.T. (2022a). Optimization and identification of lactic acid bacteria with higher mannitol production potential. Indian Journal of Animal Research, 1, 8. doi: 10.18805/IJAR.B-4759. DOI: https://doi.org/10.18805/IJAR.B-4759

Saleena, L.A.K., Chandran, D., Rayirath, G., Shanavas, A., Rajalingam, S., Vishvanathan, M., Sharun, K., & Dhama, K. (2022b). Development of low-calorie functional yoghurt by incorporating mannitol producing lactic acid bacteria (Leuconostoc pseudomesenteroides) in the standard yoghurt culture. Journal of Pure and Applied Microbiology, 16(1), 729-736. doi: 10.22207/JPAM.16.1.78. DOI: https://doi.org/10.22207/JPAM.16.1.78

Souroullas, K., Aspri, M., & Papademas, P. (2018). Donkey milk as a supplement in infant formula: Benefits and technological challenges. Food Research International, 109, 416-425. https://doi.org/10.1016/j.foodres.2018.04.051 DOI: https://doi.org/10.1016/j.foodres.2018.04.051

Tafaro, A., Magrone, T., Jirillo, F., Martemucci, G., D'Alessandro, A.G., Amati, L., & Jirillo, E. (2007). Immunological properties of donkey's milk: its potential use in the prevention of atherosclerosis. Current Pharmacology Design, 13(36), 3711-3717. https://doi.org/10.2174/138161207783018590 DOI: https://doi.org/10.2174/138161207783018590

Tidona, F., Charfi, I., Povolo, M., Pelizzola, V., Carminati, D., Contarini, G., & Giraffa, G. (2015). Fermented beverage emulsion based on donkey milk with sunflower oil. International Journal of

Food Science & Technology, 50(12), 2644-2652. https://doi.org/10.1111/ijfs.12936 DOI: https://doi.org/10.1111/ijfs.12936

Vincenzetti, S., Pucciarelli, S., Polzonetti, V., & Polidori, P. (2017). Role of proteins and of some bioactive peptides on the nutritional quality of donkey milk and their impact on human health. Beverages, 3(3), 34. https://doi.org/10.3390/beverages3030034 DOI: https://doi.org/10.3390/beverages3030034

Vincenzetti, S., Santini, G., Polzonetti, V., Pucciarelli, S., Klimanova, Y., & Polidori, P. (2021). Vitamins in human and donkey milk: functional and nutritional role. Nutrients, 13(5), 1509. https://doi.org/10.3390/nu13051509 DOI: https://doi.org/10.3390/nu13051509

Zhou, X., Tian, X., Song, L., Luo, L., Ma, Z., & Zhang, F. (2022). Donkey whey protein and peptides regulate gut microbiota community and physiological functions of D-galactose-induced aging mice. Food Science and Nutriiton, 11(2), 752-764. https://doi.org/10.1002/fsn3.3111 DOI: https://doi.org/10.1002/fsn3.3111

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2023-04-30

How to Cite

P R, D., C S, D. D., Dev, B. S., Jayan, J., P S, H., Rajan, N. S., S, K., J P, N., K G, A., M, P., Chakraborty, S., Chopra, H., Dey, A., Sharma, A. K., Dhama, K., & Chandran, D. (2023). Donkey milk: chemical make-up, biochemical features, nutritional worth, and possible human health benefits - Current state of scientific knowledge. Journal of Experimental Biology and Agricultural Sciences, 11(2), 251–263. https://doi.org/10.18006/2023.11(2).251.263

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