COMPARISON OF α –GLUCOSIDASE INHIBITORY ACTIVITY OF Moringa oleifera ETHANOLIC EXTRACT

Rizky Rahmwaty  Alami; Herlina  Rante; Yulia Yusrini  Djabir

doi:10.18006/2021.9(Spl-2-ICOPMES_2020).S269.S273

Authors

Rizky Rahmwaty Alami Faculty of Pharmacy, Hasanuddin University, Makassar, Sulawesi Selatan, 90245,Indonesia
Herlina Rante Faculty of Pharmacy, Hasanuddin University, Makassar, Sulawesi Selatan, 90245,Indonesia
Yulia Yusrini Djabir Faculty of Pharmacy, Hasanuddin University, Makassar, Sulawesi Selatan, 90245,Indonesia

DOI:

https://doi.org/10.18006/2021.9(Spl-2-ICOPMES_2020).S269.S273

Keywords:

α –Glucosidase inhibitory, Moringa oleifera, Ethanol extract, IC50, Acarbose

Abstract

The purpose of this research was to determine the α-glucosidase enzyme inhibitory activity of Moringa oleifera plant samples collected from the three geographical areas viz., Saragi, Bacuhau, and Batumatongka of Southeast Sulawesi Indonesia. Ethanol extract of Moringa leaves was prepared by the maceration method using 95% ethanol. The estimation of α –glucosidase inhibitory activity of this extract was performed in vitro. The results of the study showed that ethanolic extract of three Moringa samples i.e. Sarangi, Bacuhau, and Batumatongka had the IC₅₀value of 18.62, 10.18, 10.58 ppm, respectively while IC₅₀value for the acarbose positive control was reported 11.54ppm. From the results of this study, it can be concluded that ethanolic extract of Moringa could inhibit α –glucosidase and this potential was similar to the commercial α –glucosidase inhibitor acarbose.

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