STABILITY OF THIOAMIDE TYPE OF PIPERINE UNDER ACIDIC AND  BASIC CONDITIONS

Nurul  Hikma; Risfah  Yulianty; Muhammad  Aswad

doi:10.18006/2021.9(Spl-2-ICOPMES_2020).S259.S263

Authors

Nurul Hikma Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia 90245
Risfah Yulianty Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia 90245
Muhammad Aswad Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia 90245

DOI:

https://doi.org/10.18006/2021.9(Spl-2-ICOPMES_2020).S259.S263

Keywords:

Thiopiperine, Acidic and basic conditions, Degradation, Chromatography, Cancer

Abstract

Thioamide type of piperine, “thiopiperine” is a derivate of piperine that having high potency against breast cancer cells. This research was intended to evaluate the stability of thiopiperine under highly acidic and basic conditions for 72 h at 60⁰C. This study was conducted by the SHIMADZU^® UFLC system integrated with a PDA detector, while the analysis was performed in an isocratic separation mode using column C-18 (COSMOSIL^®), 150 mm x 4.6 mm, column particle size: 5 µm. Chromatography condition was set using a mobile phase consisting of 50% aqueous acetonitrile with a flow rate of 1 mL/min, while the detection wavelength was 340 nm. The result showed that thiopiperine undergoes extensive degradation under acidic and basic environments.

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