Arumugam VA, Thangavelu S, Fathah Z (2020) COVID-19 and the World with Co-Morbidities of Heart Disease, Hypertension and Diabetes. Journal of Pure and Applied Microbiology 14: 1623-1638.

Babcock GJ, Esshaki DJ, Thomas WD, Ambrosino DM (2004) Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with the receptor. Journal of Virology 78: 4552-4560.

Barton LM, Duval EJ, Stroberg E, Ghosh S, Mukhopadhyay S (2020) Covid-19 autopsies, oklahoma, USA. American Journal of Clinical Pathology 153: 725-733.

Bellmeyer A, Martino JM, Chandel NS, Scott Budinger GR, Dean DA, Mutlu GM (2007) Leptin resistance protects mice from hyperoxia-induced acute lung injury. American Journal of Respiratory and Critical Care Medicine 175: 587-594.

Bojkova D, Klann K, Koch B, Widera M, Krause D, Ciesek S, Münch C (2020) SARS-CoV-2 infected host cell proteomics reveal potential therapy targets. Nature Research DOI: 10.21203/rs.3.rs-17218/v1.

Buchholz UJ, Bukreyev A, Yang L, Lamirande EW, Murphy BR, Subbarao K, Collins PL (2004) Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity. Proceedings of the National Academy of Sciences 101: 9804-9809.

Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Li X (2020a) A trial of lopinavir–ritonavir in adults hospitalized with severe COVID-19. New England Journal of Medicine382:1787-1799.

Cao Y, Li L, Feng Z, Wan S, Huang P, Sun X, Wang W (2020b) Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations. Cell discovery 6: 1-4.

Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, Zhang X, et al. (2020) Clinical and immunologic features in severe and moderate forms of Coronavirus Disease. Journal of Clinical Investigation 137244. DOI:  10.1172/JCI137244.

Chiu SS, Hung Chan K, Wing Chu K, Kwan SW, Guan Y, Man Poon LL, Peiris JSM (2005) Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China. Clinical infectious diseases 40: 1721-1729.

Dhama K, Patel SK, Pathak M, Yatoo MI, Tiwari R, Malik YS, Rodriguez-Morales AJ (2020a) An update on SARS-CoV-2/COVID-19 with particular reference to its clinical pathology, pathogenesis, immunopathology and mitigation strategies. Travel Medicine and Infectious Disease 101755.

Dhama K, Sharun K, Tiwari R, Dadar M, Malik YS, Singh KP, Chaicumpa W (2020b) COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics. Human vaccines & Immunotherapeutics 1-7.

Gaur P, Saini S, Vats P, Kumar B (2018) Regulation, signalling and functions of hormonal peptides in pulmonary vascular remodelling during hypoxia. Endocrine 59: 466-480.

Gupte M, Thatcher SE, Boustany-Kari CM, Shoemaker R, Yiannikouris F, Zhang X, Cassis LA (2012) Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice. Arteriosclerosis, thrombosis, and vascular biology 32: 1392-1399.

Hamming I, Timens W, Bulthuis MLC, Lely AT, Navis GV, van Goor H (2004) Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. The Journal of Pathology: A Journal of the Pathological Society of Great Britain and Ireland 203: 631-637.

He L, Ding Y, Zhang Q, Che X, He Y, Shen H, Deng Y (2006) Expression of elevated levels of pro?inflammatory cytokines in SARS?CoV?infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS. The Journal of Pathology: A Journal of the Pathological Society of Great Britain and Ireland 210: 288-297.

Hoffmann M, Kleine-Weber H, Krüger N, Mueller MA, Drosten C, Pöhlmann S (2020a) The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells. BioRxiv doi: https://doi.org/10.1101/2020.01.31.929042.

Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Müller MA (2020b) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 181: 271-280.

Hui DS, Azhar EI, Madani TA, Ntoumi F, Kock R, Dar O, Zumla A (2020) The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—The latest 2019 novel coronavirus outbreak in Wuhan, China. International Journal of Infectious Diseases 91: 264-266.

Hussain M, Jabeen N, Raza F, Shabbir S, Baig AA, Amanullah A, Aziz B (2020) Structural variations in human ACE2 may influence its binding with SARS?CoV?2 spike protein. Journal of Medical Virology 92:1580–1586.

Ibrahim HS, Froemming GRA, Omar E, Singh HJ (2014) ACE2 activation by xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-Dawley rats. Reproductive Toxicology 49: 155-161.

Ingallinella P, Bianchi E, Finotto M, Cantoni G, Eckert DM, Supekar VM, Pessi A (2004) Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus. Proceedings of the National Academy of Sciences 101: 8709-8714.

Janson G, Zhang C, Prado MG, Paiardini A (2017) PyMod 2.0: improvements in protein sequence-structure analysis and homology modeling within PyMOL. Bioinformatics 33: 444-446.

Jayawardena N, Burga LN, Poirier JT, Bostina M (2019) Virus–receptor interactions: Structural insights for oncolytic virus development. Oncolytic Virotherapy 8: 39.

Jordan RE, Adab P, Cheng KK (2020) COVID-19: risk factors for severe disease and death.BMJ 368:m1198

Kanne JP (2020) Chest CT findings in 2019 novel coronavirus (2019-nCoV) infections from Wuhan, China: key points for the radiologist. Radiology 295: 16-17.

Keam S, Megawati D, Patel SK, Tiwari R, Dhama K, Harapan H (2020) Immunopathology and immunotherapeutic strategies in severe acute respiratory syndrome coronavirus 2 infection. Reviews in Medical Virology 30: e2123.

Klok FA, Kruip MJHA, Van Der Meer NJM, Arbous MS, Gommers DAMPJ, Kant KM, Endeman H (2020) Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: an updated analysis. Thrombosis Research 191:148-150.

Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Bao L (2005) A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury. Nature Medicine 11: 875-879.

Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR (2020) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges. International Journal of Antimicrobial Agents 55(3):105924. doi: 10.1016/j.ijantimicag.2020.105924.

Letko M, Munster V (2020) Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV. BioRxiv doi: https://doi.org/10.1101/2020.01.22.915660.

Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Choe H (2003) Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 426: 450-454.

Li W, Sui J, Huang IC, Kuhn JH, Radoshitzky SR, Marasco WA, Farzan M (2007) The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2. Virology 367: 367-374.

Liu S, Xiao G, Chen Y, He Y, Niu J, Escalante CR, Jiang S (2004) Interaction between heptad repeat 1 and 2 regions in the spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors. The Lancet 363: 938-947.

Liu MY, Zheng B, Zhang Y, Li JP (2020) Role and mechanism of angiotensin-converting enzyme 2 in acute lung injury in coronavirus disease 2019. Chronic Diseases and Translational Medicine 6(2):98-105. DOI: 10.1016/j.cdtm.2020.05.003.

Luytjes W, Sturman LS, Bredenbee PJ, Charite J, van der Zeijst BA, Horzinek MC, Spaan WJ (1987) Primary structure of the glycoprotein E2 of coronavirus MHV-A59 and identification of the trypsin cleavage site. Virology 161: 479-487.

MacIntyre CR (2020) Wuhan novel coronavirus 2019ncov–update January 27th, 2020. Global Biosecurity 1: 3.

Malik YS, Kumar N, Sircar S, Kaushik R, Bhat S, Dhama K, Zowalaty MEE (2020) Coronavirus disease pandemic (COVID-19): challenges and a global perspective. Pathogens 9: 519.

Marra MA, Jones SJ, Astell CR, Holt RA, Brooks-Wilson A, Butterfield YS, Cloutier A (2003) The genome sequence of the SARS-associated coronavirus. Science 300: 1399-1404.

Matoba Y, Abiko C, Ikeda T, Aoki Y, Suzuki Y, Yahagi K, Mizuta K (2015) Detection of the human coronavirus 229E, HKU1, NL63, and OC43 between 2010 and 2013 in Yamagata, Japan. Japanese Journal of Infectious Diseases 68: 138-141.

Miller SE, Brealey JK (2020) Visualization of putative coronavirus in kidney. Kidney International 98: 231–32.

Monteil V, Kwon H, Prado P, Hagelkrüys A, Wimmer RA, Stahl M, Romero JP (2020) Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2. Cell 181:905-913.

O'Keeffe S (2019) Aspiration pneumonia. New England Journal of Medicine 380: E40.

Penn BH, Netter Z, Johnson JR, Von Dollen J, Jang GM, Johnson T, Golovkine G (2018) An Mtb-human protein-protein interaction map identifies a switch between host antiviral and antibacterial responses. Molecular Cell 71: 637-648.

Pyrc K, Jebbink MF, Berkhout B, Van der Hoek L (2004) Genome structure and transcriptional regulation of human coronavirus NL63. Virology Journal 1: 7.

Qamar SA, Basharat K, Bilal M, Iqbal HMN (2020) Therapeutic Modalities for SARS-CoV-2 (COVID-19): Current Status and Role of Protease Inhibitors to Block Viral Entry into Host Cells. Journal of Pure and Applied Microbiology 14: 1695-1703.

Ramaiah A, Koralur MC, Dasch GA (2018) Complexity of type-specific 56 kDa antigen CD4 T-cell epitopes of Orientia tsutsugamushi strains causing scrub typhus in India. PLoS One 13: e0196240.

Ranucci M, Ballotta A, Di Dedda U, Bayshnikova E, Dei Poli M, Resta M, Menicanti L (2020) The procoagulant pattern of patients with COVID?19 acute respiratory distress syndrome. Journal of Thrombosis and Haemostasis 18:1747-1751.

Sanchis-Gomar F, Lavie CJ, Perez-Quilis C, Henry BM, Lippi G (2020) Angiotensin-Converting Enzyme 2 and antihypertensives (angiotensin receptor blockers and angiotensin-converting enzyme inhibitors) in Coronavirus Disease 2019. Mayo Clinic Proceedings 95(6): 1222-1230.

Sawalha AH, Zhao M, Coit P, Lu Q (2020) Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients. Clinical Immunology 108410. doi: 10.1016/j.clim.2020.108410.

Sievers F, Wilm A, Dineen D, Gibson TJ, Karplus K, Li W, Thompson JD (2011) Fast, scalable generation of high?quality protein multiple sequence alignments using Clustal Omega. Molecular Systems Biology 7: 539. doi: 10.1038/msb.2011.75.

Takahashi Y, Haga S, Ishizaka Y, Mimori A (2010) Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases. Arthritis Research & Therapy 12: 1-8.

Tian S, Xiong Y, Liu H, Niu L, Guo J, Liao M, Xiao SY (2020) Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies. Modern Pathology 33: 1007–1014.

Van Der Hoek L, Pyrc K, Berkhout B (2006) Human coronavirus NL63, a new respiratory virus. FEMS microbiology reviews 30: 760-773.

van der Voort P, Moser J, Zandstra DF, Kobold ACM, Knoester M, Calkhoven CF, van Meurs M (2020) A clinical and biological framework on the role of visceral fat tissue and leptin in SARS-CoV-2 infection related respiratory failure. medRxiv.

Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, Moch H (2020) Endothelial cell infection and endotheliitis in COVID-19. The Lancet 395: 1417-1418.

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Zhao Y (2020a) Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China. Jama 323: 1061-1069.

Wang L, Wang Y, Ye D, Liu Q (2020b) A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence. International Journal of Antimicrobial Agents 55(6):105948. DOI: https://doi.org/10.1016/j.ijantimicag.2020.105948.

Wang P, Chen J, Zheng A, Nie Y, Shi X, Wang W, Song X (2004) Expression cloning of functional receptor used by SARS coronavirus. Biochemical and Biophysical Research Communications 315: 439-444.

Wong SK, Li W, Moore MJ, Choe H, Farzan M (2004) A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. Journal of Biological Chemistry 279: 3197-3201.

World Health Organization, & World Health Organization. (2020). Report of the WHO-China joint mission on coronavirus disease 2019 (COVID-19).

Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Yuan ML (2020) A new coronavirus associated with human respiratory disease in China. Nature 57: 265-269.

Xiao X, Chakraborti S, Dimitrov AS, Gramatikoff K, Dimitrov DS (2003) The SARS-CoV S glycoprotein: expression and functional
characterization. Biochemical and biophysical research communications 312: 1159-1164.

Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, Chen Q (2020a) High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. International Journal of Oral Science 12: 1-5.

Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Tai Y (2020b) Pathological findings of COVID-19 associated with acute respiratory distress syndrome. The Lancet respiratory medicine 8: 420-422.

Zhang H, Zhou P, Wei Y, Yue H, Wang Y, Hu M, Guo G (2020) Histopathologic changes and SARS-CoV-2 immunostaining in the lung of a patient with COVID-19. Annals of Internal Medicine 172: 629-632.

Zhang YH, Zhang YH, Dong XF, Hao QQ, Zhou XM, Yu QT, Zhang Y (2015) ACE2 and Ang-(1–7) protect endothelial cell function and prevent early atherosclerosis by inhibiting inflammatory response. Inflammation Research 64: 253-260.