ASSESSMENT OF IL-33, TNF- α AND LEUKOTREINS B4 IN PATIENTS SERUM WITH ENTERIC FEVER

Khalil Ismail A.  Mohammed; Saad Hasan Mohammed  Ali; Suha A.  Al-Fukhar; Wifaq M. Ali  Al-Wattar; Jinan M.  Mousa

doi:10.18006/2021.9(6).851.854

Authors

Khalil Ismail A. Mohammed Clinical Communicable Diseases Research Unit, College of Medicine, University of Baghdad, Baghdad, Iraq
Saad Hasan Mohammed Ali Clinical Communicable Diseases Research Unit, College of Medicine, University of Baghdad, Baghdad, Iraq
Suha A. Al-Fukhar Clinical Communicable Diseases Research Unit, College of Medicine, University of Baghdad, Baghdad, Iraq
Wifaq M. Ali Al-Wattar Clinical Communicable Diseases Research Unit, College of Medicine, University of Baghdad, Baghdad, Iraq
Jinan M. Mousa Clinical Communicable Diseases Research Unit, College of Medicine, University of Baghdad, Baghdad, Iraq

DOI:

https://doi.org/10.18006/2021.9(6).851.854

Keywords:

Salmonellosis, Interleukin-33, Tumor necrosis Factor – α, Leukotreins B4

Abstract

Salmonella typhoid and paratyphoid are transmitted mainly by the fecal-oral route. This study was designed to find the correlation between Salmonella and IgM, IgG, and the levels of interleukin-33, TNF-α, and LTB 4. The study was carried out from March 2020 to January 2021 for the detection of Salmonellosis in 100 suspected patients with age group ranging from 17 - 69 years, who attended Baghdad teaching hospitals that had been examined and defined as suspected cases by a specialized physician with the recording of clinical manifestation. The diagnosis was done by immunochromatography method, a blood sample was taken from the patient as well as other 30 healthy controls matching in age and gender. The study included measurement of the level of interleukin -33, Tumor necrosis Factor α, and Leukotreins B4 level in sera of patients and healthy control. The results indicated that anti –salmonella IgM positive in 54 cases, anti- salmonella IgG positive in 46 cases, and 18 positive cases with both IgM and IgG. The Level of interleukin 33, Tumor necrosis Factor – α increased significantly while the serum Leukotreins B4 level decreased significantly in patients sera as compared with healthy control.