Volume 6, Issue 1, February Issue - 2018, Pages:87-107
|Authors: Sonu Ambwani*, Roopali Tandon, Tanuj Kumar Ambwani, Yashpal S. Malik|
|Abstract: Herbal remedies have been extensively used since times immemorial throughout the world. These have wide acceptability due to their time-tested therapeutic values and minimal side effects in contrast to modern allopathic medicines. Commonly, the herbal medicines are available in the form of crude extracts prepared in different solvent systems which might not only need large dose administration but also could be less effective in the form of conventional formulations. Moreover, available phyto-formulations do not have the ability for specific tissue target delivery in case of different chronic diseases. Oral administration of these herbal formulations is subjected to adverse pH, enzymatic degradation and ultimately poor gut absorption and bioavailability. With the advancements in biotechnology, genomics, and combinatorial chemistry, new, more potent and specific drug delivery systems have been envisaged during the last few decades. Constraints associated with conventional phytopharmaceuticals have been improved by designing and using “Nano Delivery Systems” (NDS). The foremost aim of NDS is to provide sustained drug release, site-specific action, and improved patient’s compliance. Nano herbal medicines can be used to target them to the specific site in the body which improves their selectivity, solubility, delivery, safety, effectiveness and thus reduces the need for administration of frequent large doses. Nanocarriers loaded with herbal drugs can carry the optimal amount of the drug to their site of action avoiding different obstructions such as low pH in the stomach, metabolism by liver so that the drug can circulate into the blood for a longer period of time. Phytopharmaceuticals with NDS thus would be helpful in enhancing the efficacy of herbal drugs.|
Aggarwal D, Nautiyal U (2016) Ethosomes: A review. International journal of pharmaceutical and medical research 4 : 354-363.
Aisha AFA, Amin MSAM, Zhari I (2014) Preparation and characterization of nano liposomes of Orthosiphon stamineus ethanolic extract in soybean phospholipids. BMC Biotechnology 14: 23-34.
Ambwani S, Tandon R, Gupta A, Ambwani TK, Chauhan RS (2015) Nanoparticles: Utility, immuno-toxicology and ethical issues. Journal of Immunology and Immunopathology 17: 68-78.
Ambwani S, Kakade DP, Kandpal D, Arora S, Ambwani TK (2016) Cytotoxic effects of gold nanoparticles exposure employing in vitro animal cell culture system as part of nanobiosafety. AIP Conference Proceedings 1724, 020091 (2016); doi: http://dx.doi.org/10.1063/1.4945211.
Ansari SH, Islam F, Sameem M (2012) Influence of nanotechnology on herbal drugs: A Review. Journal of Advanced Pharmaceutical Technology & Research 3: 142-146.
Aqil F, Munagala R, Jeyabalan J, Vadhanam MV (2013) Bioavailability of phytochemicals and its enhancement by drug delivery systems. Cancer Letters 334 : 133–141.
Arora R, Kuhad A, Kaur IP, Chopra K (2015) Curcumin loaded solid lipid nanoparticles ameliorate adjuvantinduced arthritis in rats. European Journal of Pain 19 : 940- 952 .
Bagheri L, Madadlou A, Yarmand M, Mousavi ME (2013) Nanoencapsulation of date palm pit extract in whey protein particles generated via desolvation method. Food Research International 51: 866-871.
Bakry R, Vallant M, Najam-Ul-Haq M, Rainer M, Szabo Z, Huck CW, Bonn GK (2007) Medicinal Applications of Fullerenes. International Journal of Nanomedicine 2(4): 639–649.
Balakrishnan P, Shanmugam S, Lee WS, Lee WM, Kim JO, Oh DH (2009) Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery. International Journal of Pharmaceutics 377:1-8.
Baldissera MD, Da Silva AS, Oliveira CB, Zimmermann CE, Vaucher RA, Santos RC, Rech VC, Tonin AA, Giongo JL, Mattos CB, Koester L, Santurio JM, Monteiro SG (2013) Trypanocidal activity of the essential oils in their conventional and nanoemulsion forms: in vitro tests. Experimental Parasitology 134:356–361. doi: 10.1016/j.exppara.2013.03.035.
Belletti D, Riva G, Luppi M, Tosi G, Forni F, Vandelli MA , Ruozi B, Pederzoli F (2017) Anticancer drug-loaded quantum dots engineered polymeric nanoparticles: Diagnosis/therapy combined approach. European Journal of Pharmaceutical Sciences 107: 230-239.
Bhattacharya R, Mukherjee P (2008) Biological properties of "naked" metal nanoparticles. Advanced Drug Delivery Reviews 60: 1289-1306.
Bhattacharya S (2009) Phytosomes: Emerging strategy in delivery of herbal drugs and nutraceuticals. Pharma Times 41: 9-12.
Bhokare SG, Dongaonkar CC, Lahane SV, Salunke PB, Sawale VS, Thombare MS (2016) Herbal novel drug delivery- a review. World Journal of Pharmacy and Pharmaceutical Sciences 5 : 593-611.
Bilia AR, Guccione C, Isacchi B, Righeschi C, Firenzuoli F, Bergonzi MC (2014a) Essential oils loaded in nanosystems: A developing strategy for a successful therapeutic approach. Evidence-Based Complementary and Alternative Medicine 2014:651593. doi: 10.1155/2014/651593.
Bilia AR, Isacchi B, Righeschi C, Guccione C, Bergonzi MC (2014b) Flavonoids Loaded in Nanocarriers: An Opportunity to Increase Oral Bioavailability and Bioefficacy. Food and Nutrition Sciences 5: 1212-1227.
Bisht S, Feldmann G, Soni S, Ravi R, Karikar C, Maitra A, Maitra A (2007) Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): A novel strategy for human cancer therapy. Journal of Nanobiotechnology 5: 3 DOI:10.1186/1477-3155-5-3.
Bonifácio BV, Silva PB, Ramos MA, Negri KM, Bauab TM, Chorilli M (2014) Nanotechnology-based drug delivery systems and herbal medicines: A review. International Journal of Nanomedicine 1-15.
Bonner JC (2007) Lung fibrotic responses to particle exposure. Toxicologic Pathology 35: 148–153.
Campos DA, Madureira AR, Sarmento B, Gomes AM, Pintado MM (2015) Stability of bioactive solid lipid nanoparticles loaded with herbal extracts when exposed to simulated gastrointestinal tract conditions. Food Research International 78: 131-140.
Cargnelutti LO, Denardi L, Boligon A (2016) A new biodegradable polymeric nanoparticle formulation containing Syzygiumcumini: Phytochemical profile, antioxidant and antifungal activity and in vivo toxicity. Industrial Crops and Products 83: 400-407.
Celia C, Cilurzo F, Trapasso F, Cosco D, Fresta M, Paolino D (2012) Ethosomes® and transfersomes containing linoleic acid: Physicochemical and technological features of topical drug delivery carriers for the potential treatment of melasma disorders. Biomedical Microdevices 14:119-130.
Cha C, Shin SR, Annabi N, Dokmeci MR, Khademhosseini A (2013) Carbon-based nanomaterials: Multi-functional Materials for Biomedical Engineering. ACS Nano 7:2891-2897.
Chan ES, Yim ZH, Phan SH, Mansa RF, Ravindra P (2010) Encapsulation of herbal aqueous extract through absorption with ca-alginate hydrogel beads. Food and Bioproducts Processing 88: 195-201.
Chandu V P, Arunachalam A, Jeganath S, Yamini K, Tharangini K, Chaitanya G (2012) Niosomes: A Novel Drug Delivery System. International Journal of Novel Trends in Pharmaceutical Sciences 2: 25-31.
Chao P, Deshmukh M, Kutscher HL, Gao D, Rajan SS, Hu P, Laskin DL, Stein S, Sinko PJ (2010) Pulmonary targeting microparticulate camptothecin delivery system: Anti-cancer evaluation in a rat orthotopic lung cancer model. Anti-Cancer Drugs 21: 10.1097/CAD.0b013e328332a322.
Charman WN, Chan HK, Finnin BC, Charman SA (1999) Drug delivery: A key factor in realising the full therapeutic potential of drugs. Drug Development Research 46:316–27.
Chaudhary H, Kohli K, Kumar V (2014) A novel nano-carrier transdermal gel against inflammation. International Journal of Pharmaceutics 465: 175-186.
Chen CYC, Wu CH (2008) Magnolol encapsulated by liposome in inhibiting smooth muscle cell proliferation. Journal of the Chinese Chemical Society 55: 517- 521.
Chen H, Chang X, Du D, Liu W, Liu J, Weng T, Yang Y, Xu H , Yang X (2006) Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting. Journal of Controlled Release 110: 296-306.
Chen J-G, Jiang Y, Yang Zb (2012) Preparation of triptolide ethosomes. African Journal of Pharmacy and Pharmacology 6: 1341-1347.
Chen JG, Wei L, Yu J (2013) Preparation of curcumin ethosomes. African Journal of Pharmacy and Pharmacology 7: 2246-2251.
Chen Y, Lin X, Park H, Greever R (2009) Study of artemisinin nanocapsules as anticancer drug delivery systems. Nanomedicine: Nanotechnology, Biology and Medicine 5: 316-322.
Conacher M, Alexander J, Brewer JM (2000) Niosomes as immunological adjuvants. In Uchegbu IF (Ed.) “Synthetic Surfactant Vesicles” International Publishers Distributors Ltd. Singapore, Pp. 185-205.
Conte R, Marturano V, Peluso G, Calarco A, Cerruti P (2017) Recent Advances in Nanoparticle-Mediated Delivery of Anti-Inflammatory Phytocompounds. International Journal of Molecular Sciences 18: 709; doi: 10.3390/ijms18040709.
Costa DFG, Franca JR, Ribeiro TG, Kaplan MAC, Faraco AAG, Castilho RO (2013) Development and characterization of polymeric nanoparticles as Barbatimão (Stryphnodendron obovatum) standardized fraction carrier. Advances in Bioscience and Biotechnology 4: 89-92. DOI: http://dx.doi.org/10.4236/abb.2013.41013.
Crielaard BJ, Wal VD, Le HT, Bode AT, Lammers T, Hennink WE, Schiffelers RM, Fens MH, Storm G (2012) Liposomes as carriers for colchicines derived produrgs: vascular disrupting nanomedicnes with tailorable drug release kinetics. European Journal of Pharmaceutical Sciences 45: 429-435.
Datta PK, Arora S, Ambwani S (2018) Cytotoxic effect of silver nanoparticles in cancerous HeLa cells due to enhanced oxidative stress. Research Journal of Biotechnology 13: 68-74.
Dave V, Pareek A, Paliwal S (2012) Ethosome: A novel approach of transdermal drug delivery system. International Journal of Pharma and Bio Sciences 1:439-452.
Dayan N, Touitou E (2000) Carriers for skin delivery of trihexyphenidyl HCl: Ethosomes vs liposomes. Biomaterials 21: 1879–1885.
Dhule SS, Penfornis P, Frazier T, Walker R, Feldman J, Tan G, He J, Alb A, John V, Pochampally R (2012) Curcumin-loaded γ-cyclodextrin liposomal nanoparticles as delivery vehicles for osteosarcoma. Nanomedicine: Nanotechnology, Biology and Medicine 8: 440-451.
Dilnawaz F, Singh A, Mohanty C, Sahoo SK (2010) Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy. Biomaterials 31: 3694-3706.
Dornian D, Hussein MZ, Kura AU, Fakurazi S, Shaari AH, Ahmad Z (2012) Preparation of Fe?O? magnetic nanoparticles coated with gallic acid for drug delivery. International Journal of Nanomedicine 7: 5745-756.
Dua JS, Rana AC, Bhandari AK (2012) Liposomes: Method of preparation and application. International Journal of Pharmaceutical Sciences and Research 3:14-20.
Dube A, Nicolazzo JA, Larson I (2010) Chitosan Nanoparticles Enhance the Intestinal Absorption of the Green Tea Catechins (+)-Catechin and (−)-Epigallocatechin Gallate. European Journal of Pharmaceutical Sciences 41: 219- 225.
Dwivedi P, Khatik R, Khandelwal K, Taneja I, Raju KSR, Paliwal SK, Dwivedi AK, Mishra PR (2014) Pharmacokinetics study of arteether loaded solid lipid nanoparticles: An improved oral bioavailability in rats. International Journal of Pharmaceutics 466: 321-327.
Ebrahimnezhad Z, Zarghami N, Keyhani M, Amirsaadat S, Akbarzadeh A, Rahmati M, Taheri MZ, Nejati-Koshki K (2013) Inhibition of hTERT Gene Expression by Silibinin-Loaded PLGA-PEG-Fe3O4 in T47D Breast Cancer Cell Line. Bioimpacts 3: 67-74.
Edmundson M C, Capeness M, Horsfall L (2014) Exploring the potential of metallic nanoparticles within synthetic biology. New Biotechnology 31: 572-578.
Ekambaram P, Sathali AAH, Priyanka K (2012) Solid Lipid Nanoparticles: A Review. Scientific Reviews & Chemical Communications 2: 80-102.
Ekor M (2013) The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Pharmacology 4: 177-186.
Elmowafy M, Viitala T, Ibrahim HM, Abu-Elyazid SK, Samy A, Kassem A (2013) Silymarin loaded liposomes for hepatic targeting: In vitro evaluation and HepG2 drug uptake. European Journal of Pharmaceutical Sciences 50:161-171.
Esmaeili A, Niknam S (2013) Characterization of nanocapsules containing Elaeagnus angustifolia L. extract prepared using an emulsion–diffusion process. Flavour and Fragrance Journal 28: 309–315.
Esmaeili A, Ebrahimzadeh M (2015) Preparation of Polyamide Nanocapsules of Aloe vera L. Delivery with In Vivo Studies. American Association of Pharmaceutical Scientists 16: 242–249.
Fatima GX, Rahul Raj S, Reshma I, Sandeep T, Shanmuganathan S, Chamundeeswari D (2014) Herbal Ethosomes - A Novel Approach in Herbal Drug Technology. American Journal of Ethnomedicine 1: 226-230.
Gadkari PV, Balaraman M (2015) Extraction of catechins from decaffeinated green tea for development of nanoemulsion using palm oil and sunflower oil based lipid carrier systems. Journal of Food Engineering 147: 14-23
Galib, Barve M, Mashru M, Jagtap C, Patgiri BJ, Prajapati PK (2011) Therapeutic potentials of metals in ancient India: A review through Charaka Samhita. Journal of Ayurveda and Integrative Medicine 2 : 55–63.
Gandhi A, Dutta A, Pal A, Bakshi P (2012) Recent trends of phytosomes for delivering herbal extract with improved bioavailability. Journal of Pharmacognosy and Phytochemistry 1: 6-14.
Ganesan P, Arulselvan P, Choi DK (2017) Phytobioactivecompound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status. International Journal of Nanomedicine 12: 1097–1111.
Geetha R, Ashokkumar T, Tamilselvan S, Govindaraju K, Sadiq M (2013) Green synthesis of gold nanoparticles and their anticancer activity. Cancer Nanotechnology 4: 91-98.
Gibis M, Zeeb B, Weiss J (2014) Formation, characterization, and stability of encapsulated hibiscus extract in multilayered liposomes. Food Hydrocolloids 38: 28-39.
Gomes A, Ghosh S, Sengupta J, Datta P, Gomes A (2014) Herbonanoceuticals: A New Step towards Herbal Therapeutics. Medicinal and Aromatic Plants 3: 162. doi:10.4172/2167-0412.1000162.
González-Rodríguez ML, Rabasco AM (2011) Charged liposomes as carriers to enhance the permeation through the skin. Expert Opinion on Drug Delivery 8 : 857-871.
Govindarajan Karthivashan, Palanivel Ganesan, Shin-Young Park, Joon-Soo Kim, Dong-Kug Choi (2018) Therapeutic strategies and nano-drug delivery applications in management of ageing Alzheimer’s disease. Drug Delivery, 25:1, 307-320, DOI: 10.1080/10717544.2018.1428243.
Goyal A, Kumar S, Nagpal M, Singh I, Arora S (2011) Potential of novel drug delivery systems for herbal drugs. Indian Journal of Pharmaceutical Education and Research 45: 225-35.
Greenwell M, Rahman PKSM (2015) Medicinal Plants: Their Use in Anticancer Treatment. International Journal of Pharmaceutical Sciences and Research 6 : 4103–4112.
Griggs B (1982) Green Pharmacy: A History of Herbal Medicine. Viking Press, New York.
Gunasekaran T, Haile T, Nigusse T, Dhanaraju MD (2014). Nanotechnology: an effective tool for enhancing bioavailability and bioactivity of phytomedicine. Asian Pacific Journal of Tropical Biomedicine 4 : S1–S7.
Guterres SS, Alves MP, Pohlmann AR (2007) Polymeric Nanoparticles, Nanospheres and Nanocapsules for Cutaneous Applications. Drug Target Insights 2: 147–157.
He X, Li Q, Liu X, Wu G, Zhai G (2015) Curcumin-Loaded Lipid Cubic Liquid Crystalline Nanoparticles: Preparation, Optimization, Physicochemical Properties and Oral Absorption. Journal of Nanoscience and Nanotechnology 15: 5559-5565.
Hosseini SF, Zandi M, Rezaei M, Farahmandghavi F (2013) Two-step method for encapsulation of oregano essential oil in chitosan nanoparticles: Preparation, characterization and in vitro release study. Carbohydrate polymers 95: 50-56.
Hourani R, Kakkar A (2010) Advances in the elegance of chemistry in designing dendrimers. Macromolecular rapid communications 31: 947-974.
Husch J, Bohnet J, Fricker G, Skarke C, Artaria C, Appendino G, Schubert-Zsilavecz M, Abdel-Tawab M (2013) Enhanced absorption of boswellic acids by a lecithin delivery form (phytosome®) of boswellia extract. Fitoterapia 84: 89-98.
Iram F, Iqbal MS, Athar MM, Saeed MZ, Yasmeen A (2014) Glucoxylan-mediated green synthesis of gold and silver nanoparticles and their phyto-toxicity study. Carbohydrate Polymers 104: 29-33.
Iravani S (2011) Green synthesis of metal nanoparticles using plants. Green Chemistry 13: 2638-2650
Jadhav N, Powar T, Shinde S, Nadaf S (2014) Herbal nanoparticles: A patent review. Asian journal of Pharmaceutics 8 : 1-12.
Jain K, Kesharwani P, Gupta U, Jain N (2010) Dendrimer toxicity: Let's meet the challenge. International Journal of Pharmaceutics 394: 122-142.
Jantarat C (2013) Bioavailability Enhancement Techniques of Herbal Medicine: A Case Example of Curcumin. International Journal of Pharmacy and Pharmaceutical Sciences 5: 493-500.
Jia D, Barwal I, Thakur S, Yadav SC (2015) Methodology to nanoencapsulate hepatoprotective components from Picrorhiza kurroa as food supplement. Food Bioscience 9: 28-35.
Jiang HL, Cui YL, Qi Y (2013) Microencapsulation of rutin in chitosan-coated alginate microspheres through internal gelation technique. Advanced Materials Research 716: 433-458.
Jourghanian P, Ghaffari S, Ardjmand M, Haghighat S, Mohammadnejad M (2016) Sustained release Curcumin loaded Solid Lipid Nanoparticles. Advanced Pharmaceutical Bulletin 6 : 17-21.
Juzenas P, Chen W, Sun YP, Coelho MAN, Generalov R, Generalova N, Christensen IL (2008) Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer. Advanced Drug Delivery Reviews 60: 1600-1614.
Kalele S, Gosavi S W, Urban J, Kulkarni S K (2006) Nanoshell particles: synthesis, properties and applications. Current Science 91:1038-1105.
Kalita B, Das MK, Sharma AK (2013) Novel phytosome formulations in making herbal extracts more effective. Research Journal of Pharmacy and Technology 6: 1295-1301.
Kaminskas LM, Boyd BJ, Porter CJ (2011) Dendrimer pharmacokinetics: The effect of size, structure and surface characteristics on ADME properties. Nanomedicine 6: 1063-1084.
Kannan S, Dai H, Navath RS, Balakrishnan B, Jyoti A, Janisse J, Romero R, Kannan RM (2012) Dendrimer-based postnatal therapy for neuroinflammation and cerebral palsy in a rabbit model. Science Translational Medicine 4: 130-146.
Kareparamban JA, Nikam PH, Jadhav AP, Kadam VJ (2012) Phytosome: A novel revolution in herbal drugs. International Journal of Research in Pharmacy and Chemistry 2: 299-310.
Karimi N, Ghanbarzadeh M, Hamishehkar H, Pezeshki A, Mostafayi H , Gholian MM (2015) Phytosome as novel delivery system for nutraceutical materials. International Journal of Current Microbiology and Applied Sciences 4: 152-159.
Kesarwani K, Gupta R (2013) Bioavailability enhancers of herbal origin: An overview. Asian Pacific Journal Of Tropical Biomedicine 3: 253-266.
Khan A, Shukla Y, Kalra N, Alam M, Ahmad MG, Hakim SR, Owais M (2007) Potential of diallyl sulfide bearing pH-sensitive liposomes in chemoprevention against DMBA-induced skin papilloma. Molecular Medicine 13: 443-451.
Kingston DGI (2011) Modern natural products drug discovery and its relevance to biodiversity conservation. Journal of Natural Products 74:496–511.
Krausz AE, Adler BL, Cabral V, Navati M, Doerner J, Charafeddine RA (2015) Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent. Nanomedicine 11:195-206 doi: 10.1016/j.nano.2014.09.004.
Krug HF, Wick P (2011) Nanotoxicology: an interdisciplinary challenge. Angewandte Chemie International Edition 50: 1260-1278.
Kumar AB, Habbu P, Thimmasetty L, Hullatti P, Kumar RS (2017) Phytosomes as Novel Drug Delivery System for Herbal Medicine – Systematic Reviews in Pharmacy 8: 5-7.
Kumar K, Rai AK (2012) Evaluation of ant-inflammatory and anti-arthritic activities of floating microsphere of herbal drug. International Research Journal of Pharmacy 3 : 186-193.
Kumar KP, Radhika P, Sivakumar T (2010) Ethosomes-a priority in transdermal drug delivery. International Journal of Advances in Pharmaceutical Sciences 1: 111-121.
Kumar P, Kulkarni PK, Srivastava AA (2015) Pharmaceutical application of nanoparticles in drug delivery system. Journal of Chemical and Pharmaceutical Research 7: 703-712.
Kumbhani J, Tank C, Upadhyay J, Darshit R, Nirali T, Hetal S (2016) Nanoparticle: A Promising carrier for Novel Drug Delivery. International Journal of Pharma Research & Review 5 : 27-40.