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Full Text: 1 Introduction Zoonoses are the infectious diseases of animals (usually vertebrates) that naturally transmit to humans via direct contact and indirect routes, and pathogens causing zoonotic diseases pose high public health concerns (Greger, 2007; Tomley & Shirley, 2009; Wang & Cremeri, 2014; Klous et al., 2016; Tian & Tong, 2017). Sometimes human also act as a source of infection for animals in a close contact environmental settings referred as zooanthroponosis (reverse zoonoses) (Messenger et al., 2014). In last two decades, a large number of new infections like Ebola, Zika, Dengue etc., with severe life-threatening and economic consequences have emerged (Singh et al., 2017; Munjal et al., 2017). Under-diagnosis of zoonotic diseases reflects the limited capacity and coverage of health services particularly among poor people. Over the last two decades, the most emerging diseases / pathogens which have been identified are of viral origin viz. Nipah virus, Rift Valley fever, Hendra virus, Pox, Hanta virus, Severe Acute Respiratory Syndrome, Middle East Respiratory Syndrome, Ebola, Zika fever, West Nile virus, Influenza, Rabies, Hepevirus, Japanese Encephalitis, Crimean–Congo hemorrhagic fever, Chikungunya and others (Dhama et al., 2013a; Dhama et al., 2013b; Singh et al., 2017; Munjal et al., 2017). Except for the newly emerging zoonoses such as Ebola, Zika, and highly pathogenic avian influenza H5N1, the majority is not prioritized by health systems at national and international levels and are, therefore, being neglected over the time. Gastroenteritis is caused by several infectious pathogens including viruses (Rotavirus, Norovirus, Sapovirus), bacteria (Salmonela, Shigella, Helicobacter etc.) parasites (Giardia, Cryptosporidium, Entamoeba etc.) and fungus (Staphylococcus aureus, Clostridium sp., etc.), and among these all, viruses are the leading cause of acute gastroenteritis. Among enteric pathogens, viruses constitute the major threat as there is a lack of proper therapeutic interventions. The common viral agents responsible for causing enteric infections are Rotavirus, Astrovirus, Picobirnavirus, Norovirus, Sapovirus, Hepatitis E virus, Kobuvirus, Parechovirus, etc. (Dhama et al., 2009; Malik et al., 2014a; Dhama et al., 2015; Sircar et al., 2016). Severe diarrhoea, vomition and pyrexia indicates for the clinical illness associated with enteric infections, leading to major loss and economic burden across the globe. Along with respiratory tract infections, enteric infections have been pooled in the most common infectious disease syndromes for humans and animals as well and that too in all age groups (Malik & Matthijnssens, 2014; GBD 2015 Disease and Injury Incidence and Prevalence Collaborators, 2016). Nearly 5 billion diarrhoeic cases occur globally every year and 15-30 % of these severely affected lose their lives, particularly in developing countries with marginal and low income (Tate et al., 2008; Parashar et al., 2009; Malik & Matthijnssens, 2014). Faecal samples of diarrhoeic cases have been found to be responsible in circulating the enteric viruses, especially certain strains like G and P genotypes of rotavirus A in case of bovines (Prasad et al., 2005; Kusumakar et al., 2010), rotaviruses from avian (Dhama et al., 2015), picobirnaviruses from domestic pigs (Ganesh et al., 2012a). To break the jinx, hand-sanitizers and disinfectants are very helpful in containing certain zoonotic diseases transmitted through unhygienic surroundings, especially where reservoirs are in close contacts (Patnayak et al., 2008). The host’s immunomodulation is the best strategy to defeat the pathogens and Toll like receptors (TLRs) possessing innate characteristic, mediate to destabilise the infection developments (Malik et al., 2013). Recent advances in the fields diagnosis, surveillance and monitoring, immunology, developing effective vaccines, drugs and therapeutics, and adapting appropriate hygiene and biosecurity measures along with a collaborative efforts of medical and veterinary professionals need to be explored to full potential to curb the transmission and zoonotic impact of enteric viral infections (Kahn et al., 2007; Zinsstag et al., 2007; Asokan et al., 2013; Monath, 2013; Dhama et al., 2014; Dhama et al., 2015; Shanko et al., 2015).  The present review highlights few of the important enteric viruses with a focus on their zoonotic potentials as evidenced on molecular epidemiological studies, genetic diversity, phylogenetic analysis, ecology, inter-species transmission and evolutionary genetic events. These might be responsible for emergence of new variant viruses which cross the species barriers and acquire ability to cause infections in other species with a particular reference to animal viruses affecting humans and adapting to cause zoonosis. 2 Rotaviruses Amongst all enteric viral infections, rotaviruses are the leading causes of mortality and losses. They were first identified in 1969 and 1973 in fecal samples of diarrheic cattle and stool extracts of diarrheic children, respectively (Bishop et al., 1973). The genus Rotavirus within the family Reoviridae comprises of eight groups (RVA, RVB…., RVH) and two tentative groups I (RVI) and J (RVJ) based on the inner capsid protein (VP6) (Bányai et al., 2017). Rotavirus A has been identified as one of the major causes of severe acute gastroenteritis and mortality in young children and animals. Significant variations and diversity within the rotaviruses may be due to the point mutations, re-assortment and rearrangements within the genome of double-stranded, 11 segmented RNA. Rotaviruses are generally transmitted intra-species specifically, with a possibility of cross-species transmission (Martella et al., 2010). Rotaviruses are generally transmitted intra-species specifically, with a possibility of cross-species transmission (Dhama et al., 2009; Li et al., 2016). Various cases have been studied worldwide as well as in India, and have been found that animal rotaviruses can infect humans (Kang et al., 2005). Comparison between genetic sequences of humans and animals rotaviruses, has disclosed a close identity. Identifying the incidents of uncommon strains at low rate and least generation of reassortants in the human population, prompting the researchers to suggest the continuous transmission of genetic sequences of rotaviruses from animals to humans at a very low level are necessary. In rural areas, animals and humans live in close vicinity, creating an easy and quick zoonotic transmission between interspecies and generation of reassortants and virus variants. Rotavirus strains are much diversified and their epidemiology has been widely studied presenting it to be the most prevailing cause of gastroenteritis among various host species in context of Indian scenario (Basera et al., 2010; Kattoor et al., 2013; Malik et al., 2014b). Certain animal rotavirus strains have exhibited antigenic similarities to human strains, observed using RNA–RNA hybridization assays. Phylogenetic analyses of human and animal rotavirus genome reveal repeated intersections between the strains evolution, which is probably a consequence of multiple gene reassortments. The interspecies transmission and subsequent reassortments are the important mechanisms driving the diversity of rotaviruses and enabling the emergence of new pathogenic strains with altered virulence. A report of human rotavirus group A gastroenteritis in North-eastern India has documented porcine to human zoonotic transmission (Mukherjee et al., 2009). Phylogenetic analysis of human rotavirus A from Denmark showed genetic relatedness with ovine and caprine origin rotaviruses (Midgley et al., 2012). The presence of human-like Rotavirus C (RVC) in Indian pigs appears to be the first report of RVC in Indian swine population, which supports its subsequent zoonotic prospective (Kattoor et al., 2017). There are also reports of detection of canine origin rotavirus A from humans (Wu et al., 2012) and reassortment between feline and human rotaviruses (Martella et al., 2011). Reverse zoonoses (zooanthroponosis) has also been reported among rotaviruses from Haryana state, northern India, where two ovine samples showed higher similarity with human group A rotavirus (RVA) at the nucleotide and amino acid sequence level (Choudhary et al., 2017). The amplification of two ovine samples with human rotavirus gene-specific primers, sequence identity and phylogenetic analysis strongly suggests the zoonotic transmission of human RVA to sheep. There is ample scope to develop newer methodologies to diagnose the new viral variants and curb the infection at an early stage. In this direction, multiple antigenic synthetic peptide, a synthetic peptide aptamers is leaping to occupy a central position, to be established in the fast and reliable diagnosis of conserved sequences of phylogenetically common viruses (Joshi et al., 2013). Some sporadic cases of RVH have also been reported in pigs in USA, Brazil, China and Japan (Wakuda et al., 2011; Marthaler et al., 2014; Molinari et al., 2015). Sequence analysis of the porcine RVH from South Africa is showing relationship with humans from Asia and partial sequence identity with Bats in Cameroon. 3 Astroviruses Equally important after rotavirus is Astrovirus, which belongs to the family of Astroviridae, and consists of single-stranded positive-sense RNA viruses with a star-like appearance under the electron microscope (Appleton & Higgins, 1975). This virus family comprises of two genera, Avastroviruses, found in birds and the Mamastroviruses, found in mammals. Astroviruses have shown high genetic diversity along with affecting broad host range including humans, bovine, swine, ovine, minks, dogs, cats, mice, chicken, and turkeys (De Benedictis et al., 2011). The mammalian viruses are often associated with gastroenteritis in most mammalian species, whereas the avian strains are known to cause both intestinal and extra-intestinal diseases (Kapoor et al., 2009), although economic losses due to reduced growth rate and productivity are yet to be established. In children, infection caused with astrovirus is comparable to rotavirus infections, as the most common cause of gastroenteritis whereas in case of animals, no correlation has been established among them except turkey and mink astrovirus. Genetic variability has been described in almost all astrovirus species but bat and pig astroviruses possess the highest diversity thus serving as a potential reservoir for human infection (Vu et al., 2017). Genetic analysis of ORF2 from porcine astrovirus put forward a close relationship with human astrovirus (Ulloa & Gutierrez, 2010). Based on a phylogenetic analysis on viral polymerase (RdRp) gene it has been found that bat astroviruses may have a great zoonotic potential and needs further investigations to provide new insights into the ecology and evolution of astroviruses (Chu et al., 2010). To confirm the zoonosis events by in-silico analysis, we analysed few porcine and human origin astrovirus strains. The phylogenetic analysis was performed among those sequences and important information was inferred based upon their clade formation  (Figure 1). The analysis was done using the MEGA 6.0 software applying the neighbour–joining algorithm with the support of 1000 bootstrap replicates. Although, the tree constructed for astrovirus represents the porcine sequences in a single major clade, but few porcine and human strains form another clade with 100% bootstrap support (Figure 1).

The highlighted clade shows porcine and human strains alongside each other in a single clade suggesting possible zoonotic transmission between the species. In astroviruses a number of lineages have been described after the continuous surveillance studies conducted on human as well as pig population. The large number of variations in the astrovirus genome results in formation of different lineages in porcine and  human. The continuous variations could be responsible for the emergence of more virulent strains that may become zoonotic in nature and can cause infection to both porcine or humans and vice-versa. 4 Caliciviruses During the last two decades, members of the family Caliciviridae
, including Noroviruses (NoVs) and Sapoviruses (SaVs) have appeared as a cause of widespread gastroenteritis and food-borne illness. Bivalve molluscs have a high capability of filtration and, they can even concentrate virus from contaminated water. Consumption of these molluscs as raw food by humans becomes a source of the significant cause of infection with caliciviruses (Bank-Wolf et al., 2010). Norovirus genus comprises viruses that infect a wide range of hosts including humans, pigs, cattle, and mice of all ages and in closed surroundings can lead to huge outbreaks. This wide range of hosts creates the possibility for zoonotic transmission of this viral infection (Johnson et al., 2015). Infection can be transmitted either indirectly or directly, through the food chain or animal contact. Cross-species transfer of animal virus to humans can have more drastic implications than those conventionally associated with NoV (Mattison et al., 2007). At present, amino acid sequence alignment of the major capsid protein is the base to classify the NoV strains into five genogroups (Zheng et al., 2006). Reports show existence of antibodies against animal NoVs in humans and vice-versa (Widdowson et al., 2005). The ability of human NoV to replicate and induce immunity in gnotobiotic pigs, indicates the capability of pigs to serve as reservoirs for humans (Cheetham et al., 2006). In addition, genetic similarity between human and swine NoV strains increases the chances for sub-clinically infected adult pigs to act as a reservoir and the emergence of subsequent co-infection in porcine human recombinants. Cattle can also be infected with NoV; however, this strain is less closely related to the human NoV (Menon et al., 2013). Very little information is available on immunology background and the reason for short-lived immunity of NoVs, though vaccine development has been initiated. Protection is found to be more promising in asymptomatic as well as symptomatic children but little success in adults. More than one administrative routes with multiple capsid VLPs, even an admixture of rotavirus capsid protein, offer more hope in prevention.   Sapovirus (SaV) is a member of genus Sapporo-like viruses in the family Caliciviridae. It has the capability of infecting both humans and animals. Using electron microscopy it was first time identified in the United States in 1980 (Saif et al., 1980) and later based on its viral protein 1 (VP1) and polymerase (RdRp) are divided into seven genogroups, namely I to VII, where genogroups I, II, IV and V include human viruses and genogroup III, VI, and VII infects pigs, cows and mink (Jun et al., 2016). Missing sharp demarcation for host specificity and high genetic diversity indicates the co-evolution of both human and animal SaV (Reuter et al., 2010). Sapovirus is among the few culturable enteric caliciviruses. Recently, amino acid substitution in the VP1 capsid region has been found to be the base adopted by SaV for the culture in the porcine Cowden strain, boosting the desire to culture other non-culturable viruses.  5 Hepatitis viruses Hepatitis E virus (HEV) is another significant enteric zoonotic viral disease. Few animal hosts’ viz. swine, wild boars, and deer have been identified as the reservoirs of this disease. It has acquired the status of leading cause of hepatitis in human’s worldwide (Kamar et al., 2012; Mirazo et al., 2014). In general, HEV associated conditions are self-limiting and recovery comes within 3 months from appearance of symptoms. However, estimates submits involvement of nearly 20 million cases every year, where more than 3 million cases exhibit symptoms and approximately 50,000 succumb to deaths globally (Kamar et al., 2012). It is a single-stranded, positive-sense RNA virus in the Hepeviridae family. The first existence of HEV was suggested during an outbreak of hepatitis in Kashmir Valley in 1978 (Khuroo, 1980). HEV, so far belong to the Orthohepevirus genus that is divided into four species: Orthohepevirus A, B, C and D and, among these main genotypes belong to the Orthohepevirus A (HEV?1 to 4). HEV?1 and HEV?2 infect only humans and are associated with large waterborne epidemics, whereas HEV?3 and HEV?4 infecting humans and other animals, causing endemic cases of hepatitis E (Doceul et al., 2016; Tedder et al., 2017). The HEV GT1 shows higher intensity and fatality in immunocompromised patients which may reach to 25% and in endemic regions may affect more than 50% cases with acute viral hepatitis (Kamar et al., 2012). Usually, HEV transmission occurs from contaminated water but at a times few cases appears with animal based transmission also. In humans, the source of infection is associated to contact with infected animals or to consumption of raw or undercooked meat (Takahashi et al., 2004; Meng, 2011; Park et al., 2016). A large scale survey in Vietnamese pigs and human population evidenced zoonotic transmission of HEV genotypes (GT), particularly GT3 and 4 (Berto et al., 2017). Overall, the HEVs zoonotic spread has been well documented globally and thus HEV GT3 and 4 are of major concern to be tackled. 6 Picobirnaviruses Among most recently identified virus family, the Picobirnaviridae, picobirnaviruses (PBVs) are the small, non-enveloped, bi-segmented double-stranded RNA genomic viruses affecting a wide range of vertebrate hosts (Malik et al., 2014a). PBVs have been frequently detected as a co-infection along with other diarrhoeal agents and in some cases, prolonged shedding has been noticed (Ganesh et al., 2012b). In pigs and other animal hosts, matching patterns of PBV infection have also been detected (Geng et al., 2011). The increasing amount of PBV phylogenetic data based on segment 2 (RdRp) gathered from molecular epidemiological studies has evidenced a great genetic diversity of PBVs in various hosts and environmental samples. There are two genogroup (I and II) circulating throughout the world. Evidence are available on high genetic relatedness between human and porcine PBVs, human and equine PBVs and, human and rodents PBVs, suggesting extant crossing points in the ecology and evolution of heterologous PBV strains (Malik et al., 2014b; Kattoor et al., 2016). Very recently, Picobirnavirus has also been detected in dogs and bats, Vervet monkeys, wolves (Conceicao-Neto et al., 2016) on the basis of complete genome sequence 2. To confirm the zoonosis events by in-silico analysis we analysed few porcine and human origin PBV strains isolated world over (Figure 2). The phylogenetic analysis was performed among those  sequences and inferred some important information based upon their clade formation. The analysis was done using the MEGA 6.0 software applying the neighbour–joining algorithm with the support of 1000 bootstrap replicates. Huge diversity was observed among the PBV sequences with both porcine and human origin strains dispersed all over the phylogeny (Figure 2). Strains represented by the black dots are reference PBV strains. The tree shows different human and porcine strains in different clades pointing towards continuous zoonoses events going on between both species. Being a segmented virus the chances of reassortment among PBVs increases as their bipartite nature supports the events leading to formation of new variants. Therefore, the probabilities regarding the emergence of zoonotic strains are always likely to occur. Hence, frequent zoonosis events from porcine to human in PBVs are often reported and pigs are predicted to harbour these infectious strains which could become a putative threat to human health. 7 Role of Wildlife in Zoonoses Wildlife is considered as reservoir for nearly 75% of zoonotic infections. Rabies and West Nile virus were among the most common examples, whose history is well known (Marr & Calisher, 2003). Recent emerging diseases like SARS, AIDS, avian influenza have been tracked in wildlife animals and have travelled to humans. This is just because of the invasions made by humans to their habitats and claims they imbue. These transmissions are either direct or through the vectors (insects, rodents, etc.) from one species to another (Bengis et al., 2004). It can also be through the shedding of viruses in animal discharges like faeces, nasal, respiratory discharges. Birds carry some of the pathogens to a long distance through aerial routes while their seasonal migrations. Thus, their surveillance becomes necessity to check the spread of viruses and to create a clear demarcation for preventing the further extension deep in the line. Now close relations with wild animals is also a threat for the transfer of few viruses from the authorized serving personnel’s to the main stream society. The changes in the agro-climatic conditions, migrations and anthropogenic factors are also helping in the evolution of new viruses at a much rapid pace now. Efforts to cut the direct transmission may help to reduce the economic burden. 8 Conclusion and future prospects Enteric viral infections are the well-recognized cause of substantial losses and health problems both in developed and developing countries. With the advent of next-generation sequencing methodology and other state-of-art tools, several uncommon viruses have been detected in the patients suffering from gastroenteritis. Constantly increasing proofs are ascertaining that direct transmission of virus or reassortment among one or several genes may be the reason and asserting the capability of transmission of animal enteric viruses to infect humans These viruses may affect people of all age groups, often transmitted by fecal-contaminated food or water, and thus controlling these pathogens through enhancing public health hygienic measures and adapting strict biosecurity principles is of utmost importance. For the reassortment of the genes, mixed infections is the basic necessity. To track the co-circulating viruses and to study the insight for better understanding and establishing the co-relation, surveillance of human as well as animal virus strains is a critical step. With this, the strategic and strict control of the animal movement within the country and across the international border is also needed. Investigations at the global level will provide the important information regarding the diversity, prevalence, genetic heterogenicity, pathogenic potentiality, interspecies transmission ability and epidemiology of these zoonotic viruses. For the in-depth understanding and to curb such prevailing, emerging/ or re-emerging enteric viral infections we have to gather urgently sound scientific information on these pathogens including their reservoir hosts, immunopathology, genetic diversity and the development of modern diagnostic tools as well as strengthening the recent advances for designing and developing effective drugs and therapeutic regimens. There is necessity to implement the One-Health approaches while dealing with the zoonotic infectious. Implementation of public health control measures would be crucial in reducing disease affliction and developing preparedness well in advance to mitigate the losses associated with disease epidemics. Therefore, this is the apt time to establish trust worthy relationship between the animal health and public health services. A comprehensive approach will also include regular inclusion of wildlife including linked ecosystems. Lately, the concept of “One Health,” and its usefulness has been understood thoroughly, the only point remains is its implementation. Acknowledgement All the authors acknowledge and thank their respective Institutes and Universities. Funding This compilation is a review article written, analysed and designed by its authors and required no substantial funding to be stated. Conflicts of interest All authors declare that there exist no commercial or financial relationships that could in any way lead to a potential conflict of interest.  
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