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Volume 7, Issue 1, February Issue - 2019, Pages:95-102

Authors: Chandravathany Devadason
Abstract: The salmon louse, Lepeophtheirus salmonis, is a crustacean ectoparasite of salmonids and causes significant economic losses in Atlantic salmon farms. This study investigated the cellular inflammatory response, specifically macrophage migration, to the attachment of salmon louse to the epidermis of Atlantic salmon (Salmo salar). During the inflammatory response, macrophage infiltration is common at the site of infection in the host macrophages possessing phagocytic activity. The aim of the study was to investigate the immunological response of macrophages to the parasitic excretory and secretory product (E/S). The E/S of the parasites collected from the explants and in vitro cultures of parasites and macrophages isolated from fish blood were used. A macrophage migration and a phagocytosis assay were performed to study the inflammatory response. The inhibition of the macrophage migration response (p<0.05) and a significantly lower level of phagocytosis (p<0.05) were observed. The results indicate that the anti-inflammatory response of the host is elicited during louse infection.
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