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Volume 6, Issue 6, December Issue - 2018, Pages:997-1003

Authors: Nouran Y. Hamed, AhmedKandeil, Jamal S. M. Sabir, Salah E. M. Abo-Aba, Nahid H. hajrah, Mohammad K. Al-ghamdi, Alawiah M. Alhibshi, Abdelfatteh El Omri, Areej K. Al-gamdi, Mohamed A. Ali
Abstract: Many avian influenza vaccines are currently used to treat avian influenza virus’s infection in many countries of Middle East. Information about the role of antigen content in vaccine efficiency is vital for the choice of ideal vaccines and vaccination programs, in addition to licensing of new avian influenza (AI) vaccines. In present work, we studied the serological response of SPF chicken towards 7 different concentrations of avian influenza H5N1 virus (8HA, 16HA, 32HA, 64HA, 128HA, 256HA, 512 HA). Different concentrations of the vaccine strain of H5N1 virus were prepared and mixed with an adjuvant to prepare experimental vaccines with different concentrations of antigen content. Serological responses of post vaccinated chickens were monitored over the course of 6 weeks. After calculation of hemagglutination inhibition (HI) values for each group to determine the antibody titers, it was found that the maximum antibody levels were produced by antigen contents 512 and 256 HAU. Results of the present study indicated that low antigenic groups have promising protective effect.
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