Volume 6, Issue 5, October Issue - 2018, Pages:862-870
Authors: Zahra Ali AL-Balawi, Hala Salim. Sonbol
Abstract: Cerebral palsy (CP) is a common disorder in children. Dickkopf-1 (Dkk1) inhibits the canonical Wnt signaling pathway. The study aimed to assess the serum levels of Dkk1 in boys with CP and to evaluate its correlations with body mass index (BMI) and bone turnover markers (BTMs).This study included 32 Saudi boys with different physical disabilities as a result of CP and muscular dystrophy and 39 healthy Saudi boys were enrolled as a control group. The serum levels of Dkk1, N-terminal propeptide of type I collagen (P1NP), bone alkaline phosphatase (B-ALP), and C-terminal cross-linking telopeptide of type I collagen (β-CTX) were measured using enzyme link immunosorbent assay (ELISA) kits. Serum Dkk1 levels were higher in boys with CP than in controls. Further, level of PINP, TSH, FT4, calcium, and phosphorus were also reported significantly higher in CP boys than in controls. While, level of BMI, β-CTX, 25-hydroxyvitamin D and PTH were significantly lower in patients than in controls. Serum Dkk1 levels were moderately correlated with calcium (????=0.361, ????=0.0240) in the controls. Dkk1 may play a role in bone loss in boys with CP experiencing weight loss. Dkk1 could aid in the assessment of boys with CP and abnormal bone turnover.