Abstract


Volume 6, Issue 5, October Issue - 2018, Pages:850-861


Authors: Abdulaziz M. Hakami, Mohammed I. Qadri, Khalid Al-Ghamdi, Naser A. Alkenani, Zaki Monawar Eisa, Tareq K. Khawaji, Tariq A. Hamzi, Marwah Bakri
Abstract: Since 1994, Saudi Arabia was reported dengue-free country, but later prodigious dissemination of the disease in various geographic locations and outbreaks have been reported. To date, dengue virus (DENV) prevailing and serotype circulating in human blood at Jazan area has limited information. The objective of the current study was to detect and serotype DENV as base data for regional epidemiology and for future control strategies. A total of 189 blood samples from acute febrile illness subjects all (age, sex and nationality) admitted to 13 hospitals at Jazan area were collected. Sera were harvested and were subjected to molecular (Reverse Transcriptase Polymerase Chain Reaction) and to serology (ELISA). The results demonstrated that, secondary DENV was more commonly detected among 25-65 age groups of patients followed by < 15 years old patients. Primary DENV infection was mostly detected among young (< 15) patients and not among elderly (> 65) persons.  Out of 189 tested samples, 44 (23.3%) are infected by primary dengue infection, 79 (41.8%) by secondary dengue and 66 (34.9%) are dengue negative. The primary and secondary dengue infections were detected throughout the year with fluctuated prevalence with significant increase (P < 0.01) during April month. The RT-PCR detected two serotypes (DENV-1 and DENV-2) and one confirmed concurrent mixed infection was observed in one patient. From the result of study, it can be concluded that age is a crucial variable factor in secondary DENV infectivity and in case fatality.
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