Abstract


Volume 6, Issue 5, October Issue - 2018, Pages:836-849


Authors: Afnan Lafai Alsulami, Munazza Gull
Abstract: In the present study, an attempt was made to understand the occurrence of secondary infections in immuno-suppressed blood cancer patients and herbal suppression of these infections. The antibacterial potential of the ethanolic and methanolic crude extracts of ten medicinal plants against five clinical microbial isolates of blood cancer cases were evaluated through disc diffusion assay. Among the tested plants Nigella sativa extract showed highest antimicrobial potential followed by Lawsonia inermis, while Ficus carica exhibited least antimicrobial activity. The maximum zone of inhibition (16mm) was observed against Streptococcus viridans by the extract of Nigella sativa. Phenolics analysis by high performance liquid chromatography ultraviolet detector (HPLC-UV) revealed that parahydroxy benzoic acid was the major phenolic acid found in Olea europaea (797.8ng/g) and Mentha longifolia (367.98ng/g) while highest concentration of gallic acid was reported from L. inermis (3936.86ng/g) and vanillic acid (1942.51ng/g) in Ficus carica. These results indicated that phenolic compounds play an important role in pathogenic bacteria’s cell growth inhibition and could be used as future antimicrobial and chemotherapeutic agent. Further, N. sativa, L. inermis, Boswellia sacra and Trigonella foenum-graecum plant extracts showed highest antimicrobial potential against microbial isolates isolated from blood cancer patients.
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