Abstract


Volume 6, Issue 4, August Issue - 2018, Pages:652-660


Authors: Hanaa M. Malik, Munazza Gull, Ulfat Omar,Taha Abdullah Kumosani, Ahmed Mahmoud Al-Hejin, Hani Z Marzouki, Archana P. lyer
Abstract: Desert truffles are well known for its medicinal and functional food values. These mushrooms are widely used for its antibacterial properties and as a source of protein in Saudi Arabia and many other countries around the world. Methicillin Resistant Staphylococcus aureus (MRSA) has been known for its virulence and multidrug resistant that became threat for hospital employees and community members. Present study was designed to test the common occurrence of MRSA isolates in hospital employees  and patients by nasal swab samplings and then evaluate the antibacterial potential of desert truffles against these MRSA. PCR assays revealed that 17 (34%) bacterial isolates of nasal carriage found MRSA positive while in case of gender no significant association was reported in MRSA positive males and females. Further it was also reported that highest rate of MRSA positive isolates was found for the age group of 20-29 years, among the youngest participants. For testing antibacterial potential of Desert truffles, two wells of 6 mm diameter were punched on Muller-Hinton Agar that already had MRSA culture, one of them filled cautiously with 100μl of Terfezia claveryi extract and the other one with 100μl of Terfezia nivea, stored at 4? for 2 hours. After incubation at 37? for 24 h, the fresh crude extracts of T. claveryi showed a significant zone of inhibition (27±7.75mm) while this inhibition was reported (22.5±11.26mm) in case of T. nivea. These findings clearly indicated that extracts has remarkable antibacterial activity against MRSA. This investigation supports the traditional use of truffles for the treatment of eye infection and proved its effectiveness against MRSA which could be considered as promising antibiotic drug in near future.
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