Abstract: A field experiment was conducted during the rabi season of 2015-16 and 2016-17 at Regional Research Sub-station, Raghunathpur, Bidhan Chandra Krishi Viswavidyalaya, Purulia, West Bengal to evaluate the post emergence herbicides application for effective weed control and influence on crop yield in maize. The treatments were arranged in a Randomized Block Design with four replications. Results of this study revealed that hand weeding recorded superiority over remaining treatments with respect to reduced weed density and increased weed control efficiency. But, it required lot of man force which was not economic to the farmer’s point of view. Among the herbicidal treatments 2, 4 D Ethyl Ester 38% EC @ 1.0 kg ha-1 was proved to be better in controlling weeds, increasing crop yield and microbial population in the rhizosphere. 2,4 D Ethyl Ester 38% EC @ 1.0 kg ha-1 was recommended as a post-emergence herbicide in rabi maize for effective and eco-friendlycontrol of weeds and getting higher grain yield.