Volume 6, Issue 1, February Issue - 2018, Pages:53-61
Authors: Oleg A. Gimadutdinow, Raisa G. Khamidullina, Ilmira I. Fazleeva,Maxim V. Trushin
Abstract: The Gram-negative enterobacterium Serratia marcescens produces a variety of hydrolases that are secreted into the surrounding medium, among them some are highly active DNA/RNA nonspecific endonuclease. This nuclease has been the focus of studies on its mechanism of action, its substrate preferences, its protein structure and its application in industrial biotechnology. Up to date several closely and more distantly related nucleases are known that together form a Serratia nuclease superfamily. Here we briefly review these different aspects of research regarding the work on Serratia nuclease.