Abstract: Zoonotic viruses own a strong capability of transmission from animals to human or vice-versa, making them more resilient to quick modifications in their genetic sequences. This provides the advantage to adapt the new changes for better survival, increasing pathogenicity and even learning ability to jump species barriers. Usually, zoonotic viral infections involve more than one host which make them more serious threat to the surrounding inter-genus species. Zoonotic infection also helps in understanding the evolutionary course adopted by the causative virus. The virus sequence based phyloanalysis has given better methods for comparative evaluation of the viral genomes in the probability of transmissions and diversity. Several animal hosts have been identified as reservoirs and for their potential zoonotic transmission abilities. The early and accurate diagnosis of emerging and re-emerging zoonotic viruses becomes inevitable to restrict and to establish correlation with the spread of these viral infections in different milieus. For the in-depth understanding of the prevailing, emerging/ or re-emerging zoonotic enteric viral infections apposite surveillance programmes would be more meaningful in curbing the virus dispersal. There is a need to gather sound scientific information on these pathogens including their reservoir hosts, immunopathology, and genetic diversity. The implementation of relevant public health control measures is crucial to reduce disease affliction in a timely manner. Here, we converse the important zoonotic enteric viruses such as rotavirus, astrovirus, calicivirus, hepatitis virus, picobirnavirus, and their variants/types that can take a devastating course, if transmission becomes irrepressible.