Volume 5 Issue 4 Article 2

Cytotoxic T cells and Cancer Therapy

 

Sandip Chakraborty1*, Shyma K Latheef2, Ashok Munjal3, Ruchi Tiwari4, Hari Abdul Samad5, Kumaragurubaran Karthik6, Rekha Khandia3 and Kuldeep Dhama7

 

1Department of Veterinary Microbiology, College of Veterinary Sciences & Animal Husbandry, R.K Nagar, West Tripura, Pin- 799008
2Immunology Section, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly- 243 122, Uttar Pradesh
3Department of Biochemistry and Genetics, Barkatullah University, Bhopal-462 026, Madhya Pradesh, India
4Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura-281001, Uttar Pradesh, India
5Division of Physiology and Climatology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly- 243 122, Uttar Pradesh, India
6Central University Laboratory, Tamil Nadu Veterinary and Animal Sciences University, Chennai, Tamil Nadu - 600051, India
7Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly- 243 122, Uttar Pradesh, India

 

Keywords: [Cancer, cytotoxicity, dendritic cells, papilloma virus, T cells, therapy]

Page No:412-427

 

Received – February 27, 2017; Revision – May 06, 2017; Accepted – August 19, 2017
Available Online - September 10, 2017

 

Abstract

 

The cytotoxic T lymphocyte (CTL, Tc) is a type of T lymphocyte/ white blood cell involved in the host’s cell-mediated immune response against cancerous cells, abnormal cells and cells infected with viruses. Signals from infected cells or cancer cells lead to the release of cytotoxins: perforin, granzymes, and granulysin by the TC cells. The activation of CTLs is mediated by the interaction of various co-stimulatory molecules as well as immune cells. Pre-eminent role of CTLs in combating cancer can be effectively applied for the active and passive immunotherapeutic approaches. Various recombinant cytokines viz., interleukins (IL)-2, 4, 7, 10, 12, 15; tumor necrosis factor (TNF) have been found to augment the production of CTL. CTLs can also be stimulated in antigen specific manner through tumor antigens which are the molecular derivatives over expressed in tumorcells due to differentiation, point mutations or viral origin. Designing and development of vaccines based on such immunogenic candidates can be executed and in majority of cases such antigens are targets for CTLs. Identification as chemotherapy and CTL-mediated killing. and validation of these CTL-specific antigens require monitoring that can be done by various new techniques including enzyme-linked immunospot (ELISPOT); tetramer analysis, proteomic analysis and detection of cytokine intracellularly. Role of CTLs in various types of cancer including lung cancer; virus-induced lymphoproliferative disease as well as cervical cancer; gastrointestinal cancer have been discussed vividly. In the present review, role and applications of CTLs in cancer therapy has been described with a special attention on focusing the genetic approaches foe adoptive CTL therapy as well

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