Volume 4 Issue 4 Article 1

The clinical significance of the combination of pathogenic therapy in children with overactive bladder syndrome (OAB) and nocturia

Morozov S L1, Guseva N B2,*, Dlin V V3 and Tonkikh E V4

1Scientific assistant, Department of Nephrology, Pirogov Russian National Research Medical, 125412 Taldomskaya str 2, Moscow, Russia
2Professor, Head of Moscow Voiding Dysfunction Centre, Speransky Pediatric Hospital, Pirogov Russian National Research Medical University, The Russian representative ICCS, 123317 Shmitovsky pr. 29, Moscow, Russia
3Professor, Head of the Department of Nephrology, Pirogov Russian National Research Medical University, 125412 Taldomskaya str 2, Moscow, Russia
4Department of Clinical Pharmacology, Burdenko Voronezh Medical Academy, 394005 Studencheskaya street, 10, Moscow, Russia

Keywords: Children, Desmopressin MELT, Nocturia and Overactive bladder

Page No: 384 - 388

Received - January 08, 2016; Revision - February 10, 2016; Accepted - April 25, 2016 Available Online - June 25, 2016

How to Cite


The aim of the present study was to identify the frequency of nocturnal polyuria in children with suffering by OAB. Further, efficacy of the oxybutynine monotherapy either individually or in combination with desmopressin MELT was also accessed in present study. In present study, total 150 patients were selected for the clinical trial at Moscow Voiding Disfunction Centre from 2007-2011. Data collected for this study were based on the intensity of urination, calendar of episodes of incontinence, results of dyuresis, uroflowmethry with determination of volume of residual urine, ultrasound examination (USE) of the kidneys and bladder. Among the examined 150 patients, only 50 respondents found suitable for the study while the rest 100 respondents were excluded from the study due to different reasons. These participants with clinical symptoms of urinary disorders were assessed by qualimetry and evaluated with 32+ 2.5 points and were randomized into two treatment groups, among these group 1 (20 patients) were treated by oxybutyninе and desmopress in MELT bedtime while the group 2 (30 patients) were treated by only basic therapy with oxybutynine. In group 1, the clinical picture is changed and the assessment of quality control has decreased towards the relief of clinical symptoms up to 22 points, on the basis of increasing the volume of the bladder and decrease nocturnal polyuria. This improvement is statistically significant reduction in the level of nocturia and 38 ± 8% in comparison with 24 hours in diuresis. The increase in the effective volume of the bladder was 31%. While in case of group 2, although a improvement in the clinical symptoms was reported (27 ± 2.5 points), and this difference was statistically significant as compared to baseline values but it is least performing treatment as compared group 1. Further, in this group, the parameters of nocturnal polyuria also not changed. Thus, it was concluded that in the imperative syndrome and nocturnal polyuria can be affectively treated by integrated application oxybutynine and desmopressin MELT.

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